局灶性脑缺血后星形胶质细胞反应性动态变化.doc

局灶性脑缺血后星形胶质细胞的反应性动态变化 星形胶质细胞已被发现在许多疾病和几乎所有形式的神经性疾病中可起到重要作用，从严重的脑损伤，如脑卒中、创伤性脑损伤、脊髓损伤到神经变性疾病如阿尔茨海默病、帕金森病，和肌萎缩侧索硬化症，这个过程被称为星形胶质细胞增生。星形胶质细胞增生的一个特点是星形胶质细胞的形态变化和神经胶质纤维酸性蛋白的表达增加。鉴于疾病发作的不同原因和病症，这些反应性星形胶质细胞的时间和空间变化是不同的；因此，对星形胶质细胞反应性动态变化的详细研究已为潜在的治疗性干预提供了大量信息。来自美国密苏里大学哥伦比亚分校的Shinghua Ding教授在2014年12月第23期《中国神经再生研究（英文版）》杂志发文，重点讨论了脑缺血动物模型梗死周围区，即缺血半影带反应性星形胶质细胞形态增强的时间和空间动态变化。由于反应性星形胶质细胞表现出干细胞样特性，因此了解反应性星形胶质细胞的胶质瘢痕形成的动态变化对于展开基于星形胶质细胞的细胞疗法治疗脑卒中十分重要。 缺血性脑卒中后不同阶段缺血半影带和胶质瘢痕形成中动态反应性星形胶质细胞的图式表征。 Article: Dynamic reactive astrocytes after focal ischemia by Shinghua Ding1, 2 (1 Dalton Cardiovascular Research Center, University of Missouri-Columbia, MO, USA; 2 Department of Bioengineering, University of Missouri-Columbia, MO, USA) Ding S. Dynamic reactive astrocytes after focal ischemia. Neural Regen Res. 2014;9(23):2048-2052. Dynamic reactive astrocytes after focal ischemia Astrocytes are specialized and most numerous glial cell type in CNS andplay important roles in physiology. Astrocytes are also critically involved in many neural disorders including focal ischemic stroke, a leading cause of brain injury and human death. One of the prominentpathological features of focal ischemic stroke is reactive astrogliosis and glial scar formation associated with morphological changes and proliferation.Prof. Shinghua Ding, from University of Missouri-Columbia, USA discusses the recent advances in spatial and temporal dynamics of morphology and proliferation of reactiveastrocytes after ischemic stroke based on results from experimental animal studies. As reactive astrocytes exhibit stem cell-like properties, knowledge of dynamics of reactive astrocytes and glial scar formation will provide important insightsfor astrocyte-based cell therapy in stroke. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 23, 2014). Schematic representations of dynamic reactive astrocytes in the penumbra and glial scar formation at different stages after a focal ischemic stroke. Artic