细胞自噬与病毒复制-中国细胞生物学学报.PDF

网络出版时间：2014-04-29 16:09 网络出版地址：/kcms/doi/10.11844/cjcb.2014.05.0433.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(5): DOI: 10.11844/cj cb.2014.05.0433 细胞自噬与病毒复制 * 朱 斐 王 徵 (浙江农林大学动物科技学院, 临安311300) 摘要 细胞自噬是真核生物中一种高度保守的细胞内容物降解过程, 在维持细胞的内环境稳 定中起着重要作用。同时, 自噬参与固有免疫系统对病原微生物的识别, 以帮助吞噬细胞进行有效 的吞噬作用并清除细胞内外的病原体。而病毒, 尤其是RNA病毒, 具有快速进化以应对宿主细胞中 的变化的能力, 能通过利用或抑制宿主细胞的自噬作用来为自身的复制服务。因此, 针对自噬途径 的药物筛选和治疗策略越来越成为抗病毒研究的热点。 关键词 细胞自噬; 病毒复制; 免疫 Autophagy and Virus Replication Zhu Fei*, Wang Zhi (College of Animal Science and Technology, Zhejiang Agriculture and Forestry University, Lin’an 311300, China) Abstract Autophagy is a highly conserved cellular degradation process in eukaryotes, playing an important role in the maintenance of cellular homeostasis. At the same time, autophagy contributes to the recognition of pathogenic microorganisms by innate immune system, and helps phagocytes to make an effective phagocytosis and clear extracellular or intracellular pathogens. However, the virus, especially the RNA virus, which has the capacity of rapid evolution to respond to the changes in the host cell, can make service for its replication through using or inhibiting autophagy. Therefore, drug screening and treatment strategies based on the autophagy pathway increasingly become a hot spot of antiviral research. Key words autophagy; virus replication; immuty 细胞自噬是细胞自身通过捕获并消化其胞质 系先天性免疫系统和适应性免疫系统的桥梁, 包括 成分来调整细胞质的质量、品质及组织构成的过