卒中后白细胞反应及其影响因素的回顾性研究.doc

卒中后白细胞反应及其影响因素的回顾性研究 甄志刚，彭延波，王大力, 韩保志 (华北煤炭医学院附属医院神经内科二病区，河北 唐山 063000) 【摘要】 目的 了解脑梗死后白细胞水平变化及其影响因素。方法 回顾性收集2004年1月～2008年12月在我院连续性住院的急性脑梗死病例902例，记录入院首次白细胞计数，对影响白细胞水平的因素进行单因素及多因素Logistic回归分析。结果 共收集急性脑梗死病例902例，其中白细胞水平升高114例( 12.64%)。经单因素及多因素logistic回归分析，白细胞水平高低与意识(OR=2.075; 95％3.770)、 NIHSS评分(OR=1.149; 95％CI: 1.095~1.205)、纤维蛋白原(OR=1.326; 95％CI1.061~1.658)、血小板(OR=1.008; 95％CI1.012)等明显相关。结论 NIHSS评分、意识水平、血小板及纤维蛋白原等是脑梗死后白细胞水平升高的独立影响因素。 【关键词】脑梗死；白细胞计数；回顾性研究 The retrospective study of WBC response and its influential factors after stroke ZHEN Zhig-ang, PENG Yan-bo, WANG Da-li, HAN Bao-zhi. Neurological department of affiliated hospital of North China Coal Medical Collage, Tangshan 063000 China 【Abstct】bjective To explore the variance of WBC level and its influential factors after cerebral infarction. Methods 902 continuous acute cerebral infarction cases having hospitalized in our hospital from January 2004 to December 2008 were retrospectively collected. The WBC count on admission was collected. The influential factors were analyzed by monovariant and multivariant logistic regression. Results 902 acute cerebral infarction cases were collected, of which 114(12.64%) cases having a WBC count exceed normal range. monovariant and multivariant logistic regression analyses showed that the WBC count was associated with consciousness (OR=2.075; 95％3.770), NIHSS total scores (OR=1.149; 95％CI: 1.095~1.205), FIB (OR=1.326; 95％CI1.061~1.658), PLT (OR=1.008; 95％CI1.012). Conclusion The results suggest that consciousness, NIHSS total scores, FIB, PLT were independent influential factors of WBC count after cerebral infarction. 【Key words】ebral infarction; WBC count; Retrospective studies 早在上世纪80年代，人们就发现部分脑梗死患者入院时外周血白细胞计数异常升高，且有报道其可能与局限性脑损伤直接相关[1]。然而到目前为止，关于脑梗死后白细胞数升高的原因还存在争论。现将本院收治的急性脑梗死患者902例白细胞水平结合临床分析报道如下。 1 资料与方法 1.1 一般资料 我院2004年1月至2008年12月收治的急性脑梗死患者902例，其中男544例，女358例，年龄30-95岁，中位年龄65岁。所有病例均符合1995年全国第四届脑血管病学术会议制定的脑梗死诊断标准[2]，且经头颅CT或MRI证实。排除标准：(1)合并或继发出血性脑卒中及瘤卒中(2)合