基于方证相应的慢性萎缩性胃炎浊毒内蕴证用药 - 天津中草药杂志社.pdf

中草药 Chinese Traditional and Herbal Drugs 第 45 卷 第 19 期 2014 年 10 月 ·2873 · 基于方证相应的慢性萎缩性胃炎浊毒内蕴证用药规律研究 1 1* 2 周盼盼 ，王彦刚 ，吕静静 1. 河北省中医院，河北 石家庄 050011 2. 河北医科大学研究生院，河北 石家庄 050011 摘 要：收集 200 例慢性萎缩性胃炎（CAG ）患者的病历，详细记录其性别、年龄、电子胃镜及病理结果、临床症状、中 药处方，并进行统计分析，以“黄金分割法”为判别依据，采用频数统计和关联规则分析进行药物与证候之间关联规则的挖 掘。研究化浊解毒方药治疗 CAG 的用药规律，探寻化浊解毒方与浊毒内蕴证稳定的方证关系。经数据处理，共得到中药 153 味，根据“黄金分割法”的原则，使用频率在 61.8% 以上（含61.8% ）的药物共有 15 种，作为 CAG 浊毒内蕴证治疗的核心 药物。出现频次最多的临床症状共 10 种，作为 CAG 浊毒内蕴证的主要症状表现。通过关联规则分析发现药物和脉证之间 具有较强相关性，说明 CAG 浊毒内蕴证与化浊解毒方方证的高度相应，体现了 CAG 的关键病机为浊毒内蕴，“化浊解毒法” 为与之相对应的治疗大法。 关键词：方证相应；化浊解毒方；慢性萎缩性胃炎；黄金分割；关联规则 中图分类号：R282.31 文献标志码：A 文章编号：0253 - 2670(2014)19 - 2873 - 05 DOI: 10.7501/j.issn.0253-2670.2014.19.026 Research on medication regularity of pattern of internal accumulation of zhuodu in chronic atrophic gastritis based on correspondence between prescription and syndrome 1 1 2 ZHOU Pan-pan , WANG Yan-gang , LV Jing-jing 1. Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang 050011, China 2. Hebei Medical University, Shijiazhuang 050011, China Abstract: To study the medication regularity of Huazhuo Jiedu Formula in treating the chronic atrophic gastritis (CAG), and to explore the stable relationship of correspondence between Huazhuo Jiedu Formula and the pattern of internal accumulation of zhuodu . Statistical analysis was conducted among 200 cases of CAG, whose case histories included their gender, age, electronic gastroscope, pathological results, clinical symptoms, and prescriptions of Chinese materia medica. On the basis of “golden section method”, the association rule between drugs and syndromes was investigated using frequency statistic method and association rule analysis. Through data processing, 153 kinds of Chinese herbal decoction were obtained. According to the principle of “golden sectio