石墨烯及其衍生物氧化石墨烯作为新型药物载体材料在肿瘤治疗领域 .pdf

PROGRESS IN PHARMACEUTICAL SCIENCES 2015,39 1 :32-39 32 ( ) ·新技术·新方法· N E W T E C H N O L O G Y A N D N E W M E T H O D 石墨烯及其衍生物氧化石墨烯作为新型药物载体材料 在肿瘤治疗领域的应用研究 * ** 赵媛媛，殷婷婕，霍美蓉 ，周建平 （中国药科大学天然药物活性组分与药效国家重点实验室，江苏 南京 210009） [ 摘要 ] 石墨烯及其衍生物氧化石墨烯因具有水溶性好、比表面积大、载药量高以及易于修饰等优势，近年来在生物医药领域尤其在肿瘤治 疗领域的应用研究发展迅速。综述石墨烯及氧化石墨烯作为新型药物载体材料所具有的特性和生物安全性、表面修饰方式以及在肿瘤靶向 递药系统中的应用，为其在生物医药领域的应用研究提供新方法和新思路。 [ 关键词 ] 石墨烯；氧化石墨烯；表面修饰；药物载体；肿瘤靶向递药；安全性 [ 中图分类号 ] O613.71; R73-36 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2015）01-0032-08 Research Advances in the Application of Graphene and Its Derivative, Graphene Oxide, as New Drug Carrier Materials in the Field of Tumor Treatment ZHAO Yuanyuan, YIN Tingjie, HUO Meirong, ZHOU Jianping ( State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China) [Abstract] The application of graphene and its derivative, graphene oxide(GO), in bio-medical field, especially in the field of tumor treatment, has been developed rapidly in recent years, owing to their good solubility in water, large specific surface area, high drug-loading capacity and easy modification. The properties, biological safety and surface modification of graphene and GO as well as their application in tumor-targeted drug delivery system as new drug carrier materials were reviewed so as to provide new method and new thinking for the research on their application in bio-medical field. [Key words] graphene; graphene oxide; surface modification; drug carrier; tumor-targeted drug delivery; safety 众所周知，癌症（肿瘤）已经成为威胁人类生命健 专一性差、全身毒副作用大等弊端，所以寻找具有靶 康的世界性问