191例氟喹诺酮类药物不良反应分析.doc

191例氟喹诺酮类药物不良反应分析摘 要 目的：调查我院氟喹诺酮类抗菌药物不良反应发生的情况和特点。方法：收集我院上报的191例氟喹诺酮类药物的不良反应报告，按患者的一般情况、涉及药物、给药方式、不良反应涉及器官及临床表现等方面进行汇总和分析。结果：不良反应主要发生在60岁以上患者中(45.02% )；女性不良反应的发生比例明显高于男性；共涉及3种氟喹诺酮类药物，主要以左氧氟沙星为主；严重不良反应事件为3例（1.57%），皆为过敏性休克；引起不良反应的主要给药途径为静脉给药(164例，85.90% ) ；不良反应主要损害类型为皮肤及其附件损害、消化系统损害。结论：加强氟喹诺酮类药物不良反应的监测工作，以减少氟喹诺酮类药物不良反应、提高临床合理用药水平。 关键词 氟喹诺酮类药物 药品不良反应 合理用药 调查分析 中图分类号：R978.1 文献标识码：B 文章编号：1006-1533(2012)03-0036-03 Analysis of 191 cases of adverse drug reactions induced by fluoroquinolones XU Hong-bing1*，TAN Ji-liang2，LI Xiao-yu1，LIU Gao-lin1** （1.Department of Pharmacy，First People s Hospital of Shanghai，Shanghai Jiao Tong University， Shanghai，200080；2. School of Medicine，Shanghai Jiao Tong University，Shanghai，200025） ABSTRACT Objective: To study the characteristics of the adverse drug reactions (ADR) induced by fluoroquinolones. Methods: A total 191 cases of fluoroquinolones-induced ADR reported in our hospital were subjected to statistical analysis with regard to the general information，the drugs involved，routes of administration，ADR-involved organs and clinical manifestations etc. Results: In all of the cases collected，adverse events were mainly involved in the aged people over 60 years（45.02%），the proportion of women was significantly higher than that of men. Three drugs of fluoroquinolones were involved，predominantly levofloxacin. Three cases were anaphylactic shock belonging to serious adverse events. 164 cases （85.59%）occurred via intravenous administration. Lesions of skin and its annex and the digestive system were the major ADR types. Conclusion: Tightening reporting and monitoring of fluoroquinolones-induced ADR may contribute to the reduction of the ADR and can improve clinical medication level. KEY WORDS fluoroquinolones；adverse drug reactions；rational drug use 药品不良反应(adverse drug reactions，ADR)是指合格药品在正常用法、正常用量下出现的与用药目的无关或意外的有害反应。ADR的发生原因有药物因素、机体因素以及用药不合理、饮食、合并用药等其它因素。氟喹诺酮类药物( fluoroquinolones，FQ)具有抗菌活性强、抗菌谱广、口服吸收好、生物利用度高、组织分布广、血浆半衰