2006-2010年间医院感染嗜麦芽窄食单胞菌分布及耐药研究.doc

2006-2010年间医院感染嗜麦芽窄食单胞菌分布及耐药研究【摘要】目的 观察2006-2010年间嗜麦芽窄食单胞菌在医院感染中的流行特征及耐药趋势,为临床用药提供参考。 方法 对2006～2010年间120株院内嗜麦芽窄食单胞菌感染的分布及药敏结果进行回顾性分析。结果 嗜麦芽窄食单胞菌在医院感染有逐年增加的趋势；120株嗜麦芽窄食单胞菌标本来源以呼吸道分泌物最多占62.50%，科室分布以重症监护病房为主占44.17%。药敏结果显示，大多数药物的耐药性都较强。10种β内酰胺类抗菌药物中除头孢哌酮/舒巴坦的耐药率低于33.4%，替卡西林/克拉维酸低于50%外，其余8种抗菌药物的耐药率严重；对氨基糖苷类抗生素中的庆大霉素、阿米卡星也呈高度耐药，耐药率均大于85%；所有抗菌药物中米诺环素的耐药率最低均低于7%，其次为左氧氟沙星与复方新诺明均低于25%。结论 嗜麦芽窄食单胞菌的院内感染率呈逐年上升的趋势，其耐药性广泛，感染后可选择的抗菌药物十分有限，临床应加强监测，尽早进行病原学检查，并根据药敏试验结果选用敏感药物，避免院内感染的爆发流行。 【关键词】嗜麦芽窄食单胞菌 感染 耐药性 中图分类号：R446.5文献标识码：A文章编号：1005-0515（2011）2-047-03 Analysis of Distribution and Antibiotic Resistance of Stenotrophomonas maltophilia Nosocomial Infection between 2006 and 2010 LIU Jingping1 ZHONG Che2 CHEN Youming ( 1 Clinical Test Laborotary of the Third Affiliated Hospital of Nanfang Medical University,Guangzhou 510630； 2 The Department of Prevention and Health Care of Hengli Hospital ,Dongguan,Guang dong 523460 ) 【Abstract】OBJECTIVE To investigate the infection characteristic and drug-resistance tendency of strains isolated from nosocomial infection patients with Stenotrophomonas maltophilia from 2006 to 2010,so asto provide evidence for clinical rational use of drugs.Methods A total of 120 patients with Stenotrophomonas maltophilia infection werestudied retrospectively from 2006 to 2010. The strains distributon and antibiotic resistance profiles were specifically analyzed. Results The annual trend of Stenotrophomonas maltophilia nosocomial infection is increasing . The 120 strains of Stenotrophomonas maltophilia were mainly islated from sputum (62.50%) specimens，and ICU was the main distribution department（44.17）. The result showed that Stenotrophomonas maltophilia had higher resistance rate to most drugs. Results of susceptibility test showed that the resistance rate of the Stenotrophomonas maltophilia to all the 10 β-lactams were high except cefoperazone/ sulbactam (lower than 33.4%) and Ticarcillin / clavulanic acid (lower than 50%). And the resistance ra