B型利钠肽水平及老年慢性心力衰竭相关性研究.docVIP

B型利钠肽水平及老年慢性心力衰竭相关性研究[摘要] 目的 探讨B型利钠肽（BNP）水平和老年慢性心力衰竭之间的相关性。方法 选取来我院就诊的确诊为慢性心力衰竭的老年患者127例，抽取其静脉血采用酶联免疫吸附法检测患者BNP水平，用统计学方法分析各心功能分级组别的BNP水平。结果 各个心功能分级组别间患者年龄比较差异均有统计学意义（P＜0.05），且患者的年龄随着心功能分级的升高而增大；各组间BNP水平比较，均有极显著性差异，且心功能分级越高，患者的年龄越大，BNP水平越高（P＜0.01）。结论 B型脑钠肽的水平与HYHA分级呈正相关，能够预示慢性心衰患者病情的严重程度，客观地反映心功能的情况，在临床上对慢性心力衰竭患者病情的诊断及危险分级具有积极的意义。 [关键词]B型利钠肽；慢性心力衰竭；心功能分级 [中图分类号] R541.6 [文献标识码] B[文章编号] 1673-9701（2011）21-117-02 The Correlative Study of B-type Natriuretic Peptide and The Aged Patients with Chronic Heart Failure ZHU Shengwen Zhejiang Province Zhongshan Hospital，Hangzhou 310005，China [Abstract] Objective To observe and study the correlative of Ｂ-type Natriuretic Peptide and the aged patients with chronic heart failure. Methods 127 aged patients with chronic heart failure were collected from Zhongshan hospital，the BNP levels was analyzed by enzymelinked immunosorbent assays（ELISA）. And the analytical method of BNP in every cardiac function class was statistics analysis. Results There was a significant difference on the age of every cardiac function class（P＜0.05）；The age was significantly increased with the severity of cardiac function classification. There was a significant difference on the BNP level in every group. The age was higher and the BNP level was higher，with the severity of cardiac function classification（P＜0.01）. Conclusion BNP level was positive with cardiac function classification. It can reflect the station of cardiac function，and have positive significance of diagnosis and classification on the patients with chronic heart failure. [Key words] B-type natriuretic peptide；Chronic heart failure；Cardiac function classification. 心血管疾病是威胁人类健康的一个重大课题，而慢性心力衰竭是各类心脏疾病发展的最终结局，是由于各种器质性或功能性心脏疾病损害心室充盈或摄血能力的一组综合征[1]，具有高死亡率及高致残率。对于心力衰竭的传统诊断主要依靠症状、体征、影像学及血流动力学检查[2]。B型利钠肽是在心室容积扩张和压力负荷增加时释放的一种神经激素，具有拮抗神经内分泌系统的激活、排钠、利尿、舒张血管的作用，参与慢性心力衰竭的发生和发展，在心功能不全时其血浓度会明显升高。研究表明B型利钠肽对慢性心力衰竭患者的诊断及预后有很重要的价值，早在2001年的欧洲心脏协会心衰诊断指南中就将利钠肽作为唯一的一个心衰的实验室诊断参考指标。笔者选取来我院就诊的老年慢性心力衰竭患