GHD患儿使用rhGH治疗效果差临床纠正.docVIP

GHD患儿使用rhGH治疗效果差临床纠正[摘要] 目的:找出GHD患儿使用rhGH治疗效果差的临床原因,及时纠正,保证疗效。方法:GHD患儿使用rhGH治疗,身高增长月平均15岁8例,月平均增高0.31 cm,复查甲状腺功能低下者4例。骨龄:15岁3例,月平均增高0.43 cm。3个月复查甲状腺功能低下者共18例,继续给左旋甲状腺素片口服。结论:GHD患儿使用rhGH治疗效果差的临床原因主要有合并甲状腺功能低下,纠正甲状腺功能低下可以改善疗效。年龄和骨龄越大,治疗效果越差,正确的诊断及正确的治疗是关键,基因的多态性和遗传性可能对疗效有影响。 [关键词] GHD;疗效;甲状腺功能;骨龄;年龄 [中图分类号] R584.2+1[文献标识码]A [文章编号]1673-7210(2009)08(c)-021-03 Correcting of the poor therapeutic effect of rhGH in child patients with GHD SHI Dingping (Children Growth Expert Clinic, Beijing 100062, China) [Abstract] Objective: To find out the reasons of poor therapeutic effect of rhGH in children with growth hormone deficiency (GHD), rectify in time and certify the treatment effectiveness. Methods: Children with GHD, undergoing rhGH, with the increase of body height less than 1 cm per month were considered as poor therapeutic effect. 126 children with GHD, undergoing rhGH for 3 months [0.1 IU/(kg?d)] in our outpatient department from January 2006 to September 2008 were observed. Results: Selected 30 children with poor treatment effectiveness, 15 were boys and 15 were girls. The mean body height of this group was 139.6 cm [(130.6±35.6) cm] after the treatment of rhGH. The increase of body height per month was 0.77 cm, per 3 months was (2.4±0.6) cm. 1 case aged smaller than 7 years old, the increase of body height per month was 2.70 cm; 8 cases aged 7-12 years old, the increase of body height per month was 0.36 cm, 5 cases were received examination of thyroid hypofunction; 13 cases aged 13-15 years old, the increase of body height per month was 0.15 cm, 5 cases were received examination of thyroid hypofunction; 8 cases aged bigger than 15 years old, the increase of body height per month was 0.31 cm; 4 cases were received examination of thyroid hypofunction; 4 cases’ bone age was smaller than 7 years old, the increase of body height per month was 0.67 cm, 1 case was received examination of thyroid hypofunction; 12 cases’ bone age was 7-12 years old, the incre