MMP-2及Fibulin-5在盆底功能障碍疾病中表达及意义探析.docVIP

MMP-2及Fibulin-5在盆底功能障碍疾病中表达及意义探析[摘要] 目的 研究MMP-2和Fibulin-5在女性盆底功能障碍性疾病（PFD）患者中的表达及其意义。 方法 用免疫组化SP法检测各30例正常对照及PFD患者阴道前壁组织中MMP-2和Fibulin-5的表达。结果 MMP-2在正常组中表达明显低于PFD组，差异有显著统计学意义（P＜0.01）；Fibulin-5在正常组中表达明显高于PFD组，差异有显著统计学意义（P＜0.01）；分娩次数对MMP-2和Fibulin-5表达影响差异无统计学意义（P＞0.05）；绝经前后MMP-2与Fibulin-5表达差异无统计学意义（P＞0.05）；MMP-2和Fibulin-5呈负相关（r=-0.495，P＜0.01）。结论 MMP-2和Fibulin-5在PFD发生发展中起着重要的作用。MMP-2及Fibulin-5对PFD疾病的发生发展影响的途径不同，MMP-2和Fibulin表达互为拮抗。 [关键词] 女性盆底功能障碍性疾病；MMP-2；Fibulin-5 [中图分类号] R711.2[文献标识码] B [文章编号] 1673-9701（2011）25-42-02 Expression and Significance of MMP-2 and Fibulin-5 in Pelvic Floor Dysfunction DONG Ke The Second Affiliated Hospital of Wenzhou Medical College，Wenzhou 325400，China [Abstract] Objective To investigate the expression and function of MMP-2 and Fibulin-5 in the patients with PFD. Methods Biopsies of vaginal wall tissue were obtained at the time of surgery from 60 women. The tissue of 30 with PFD was compared with that of 30 women with other benign conditions. The expression of MMP-2 and Fibulin-5 were detected by immunohistochemistry in vaginal wall tissue. Results The expression of MMP-2 was significantly higher in patients with PFD （P＜0.01）；but the expression of Fibulin-5 was lower（P＜0.01）；and delivery times and menopausal status have nothing to do with the expression of MMP-2 and Fibulin-5（P＞0.05）；there was a negative correlation between MMP-2 expression and Fibulin-5 expression （r=-0.495，P＜0.01）. Conclusion MMP-2 and Fibulin-5 may play an important role in the onset and development of PFD；and the method of it may different from traditional injuries. MMP-2 and fibulin-5 would antagonized each other. [Key words] Female pelvic floor dysfunction disease；MMP-2；Fibulin-5 女性盆底功能障碍性疾病（pelvic floor dysfunction，PFD）可表现为子宫脱垂等盆腔器官脱垂（pelvic organ prolapse，POP）及压力性尿失禁（stress urinary incontinence，SUI）等疾病。PFD好发于中老年妇女，是一种常见但尚未被充分认识的疾病。随着人口老龄化和对生活质量要求的提高，其发病率有增高的趋势，严重影响中老年妇女生活质量，因此究其原因、治其根本对于降低医疗支出、提高中老年妇女生活质量尤为重要[1]。目前研究认为PFD的发生与盆底支持组织结构功能完整性被破坏密