NB-UVB联合白芍总苷治疗寻常型银屑病疗效及对血清TNF-α、OPN及IL-6影响.docVIP

NB-UVB联合白芍总苷治疗寻常型银屑病疗效及对血清TNF-α、OPN及IL-6影响[摘要] 目的 观察NB-UVB联合白芍总苷治疗寻常型银屑病的临床疗效及对TNF-α、骨桥蛋白（OPN）及IL-6的影响。 方法 治疗组口服白芍总苷胶囊，同时给予NB-UVB照射；对照组只给予NB-UVB照射。 结果 治疗组有效率为92.00%，对照组有效率为76.00%，两组比较有统计学意义（χ2=8.64，P ＜ 0.05）；两组患者治疗后血清TNF-α、OPN及IL-6水平均较治疗前降低，差异有统计学意义（P ＜ 0.05），治疗组治疗后血清TNF-α、OPN及IL-6水平较对照组治疗后降低，差异有统计学意义（P ＜ 0.05）；检测结果与患者PASI评分进行Person相关性分析，结果显示：TNF-α、OPN及IL-6与PASI评分呈正相关。 结论 NB-UVB联合白芍总苷治疗寻常型银屑病可以通过抑制Th1型细胞群的功能，使Th1/Th2细胞趋向于正常状态，较单一NB-UVB治疗寻常型银屑病的疗效好。 [关键词] 寻常型银屑病；NB-UVB；白芍总苷；TNF-α；骨桥蛋白；IL-6 [中图分类号] R758.63 [文献标识码] B [文章编号] 1673-9701（2012）03-0053-03 Clinical efficacy of NB-UVB with TGP in treatment of common psoriasis and the effect on the levels of serum TNF-α, Osteopontin and IL-6 HU Yin’e WANG Bin QU Wei GAO Junling DAI Shufang Department of Dermatology, Huaihe Hospital of Henan University, Kaifeng 475000, China [Abstract] Objective To observe the efficacy of narrow band ultraviolet (NB－UVB) irradiation combined with total glucosides of paeony (TGP) capsule in treatment of common psoriasis and the influence of TGP with NB-UVB on serum TNF-α, osteopontin and IL-6 in patients with common psoriasis. Methods Patients in the treatment group were given NB－UVB irradiation, every other day, TGP Capsule 0.6 g, 3 times a day orally; Patients in the control group were given NB－UVB irradiation lonely, every other day. Results The total response rate was 92.00% for treatment group and 76.00% for control group, and there were significant differences (χ2=8.64, P ＜ 0.05). The levels of TNF-α, OPN and IL-6 were significantly decreased after treatment (P ＜ 0.05). The expression level of TNF-α, OPN, IL-6 and PASI score were positive correlation (P ＜ 0.05). Conclusion TGP capsule combined with NB－UVB in the treatment of common psoriasis could restrain the function of Th1 lymphocyte to let the regulate Th1/Th2 lymphocyte balance, and be better than NB－UVB irradiation lonely. [Key words] Common psoriasis; NB-UVB; TGP; TNF-α; Osteopontin; IL-6 我们自2010年6月～2011年8月应用窄