不同年龄组幽门螺杆菌感染及胃、十二指肠病变关系探析.docVIP

不同年龄组幽门螺杆菌感染及胃、十二指肠病变关系探析[摘要] 目的：探讨不同年龄组幽门螺杆菌（Helicobacter pylori，Hp）感染与胃、十二指肠球部病变的关系，试图为进一步完善Hp根治方案提供依据。方法：观察青年组、老年组组间及各组内不同胃、十二指肠球部病变与Hp感染的关系。结果：青年组不同胃、十二指肠球部病变均与Hp感染密切相关。老年组仅见胃、十二指肠球部溃疡与Hp感染密切相关。结论：对所有胃、十二指肠球部溃疡患者必须进行Hp根治治疗。而对于其他的胃黏膜病变者，Hp根治治疗在中青年者中意义更大。 [关键词] 幽门螺杆菌；胃、十二指肠球病变；年龄 [中图分类号]R57 [文献标识码]A [文章编号]1673-7210（2008）01（c）-102-02 Exploring the relationship between Hp infection and gastric and duodenal bulb lesions among various age groups ZHANG Bei-lin,DAI Ping,WANG Guo-liang (Baoshan Branch of Shanghai First People′s Hospital, Shanghai 200940) [Abstract] Objective：To explore the relationship between Hp infection and gastric and duodenal bulb lesions among various age groups, to further optimize the therapeutic regimens of Hp eradication. Methods：The impact of Hp infection on gastric or duodenal bulb lesions had been observed in both young and aged groups respectively. Moreover, the results were compared between these two groups. Results：The incidence of various gastric and duodenal bulb disorders in young patients was associated with Hp infection, whereas the incidence of gastric and duodenal bulb ulcers was related to Hp infection in the aged group. Conclusion：The eradication of Hp infection in patients with gastric and duodenal bulb ulcers is necessary. Of young and middle-aged groups with gastric mucosal disorders, Hp eradication is more therapeutically significant. [Key words] Helicobacter pylori (Hp);Gastric and duodenal bulb lesions;Age 笔者对不同年龄组幽门螺杆菌（Helicobacter pglori,Hp）感染与胃、十二指肠球部病变的关系进行了探讨，现报道如下： 1 资料与方法 1.1 病例选择 选取我院2005年1~12月因体检或各种不适等原因行胃镜检查，资料完整并剔除近2周服用抑酸药物?糖皮质激素?非甾体类抗炎药和抗生素者共2 179例，年龄20~85岁，其中，男1 125人，女1 054人。年龄＜65岁为中青年组（1 683例），年龄≥65岁为老年组（496例）。各组分别按胃镜和（或）组织病理学检查结果又分为对照组（浅表性胃炎组）和观察组（包括浅表糜烂性胃炎组，萎缩、肠化组，不典型增生组，胃癌组，胃溃疡组和十二指肠球部溃疡组）。 1.2 Hp阳性诊断标准 以快速尿素酶试验（试剂由上海惠泰科技公司提供）及活检组织(Warthin-Starry，W-S)染色阳性者诊断为Hp阳性。 1.3 统计学分析 所有数据以率表示，经χ2检验，以P＜0.05为差异有显著性。 2 结果 2.1 性别差异 所有入选者Hp阳性率比较，男52.1%（586/1 125），女48.2