不同热性惊厥患儿脑脊液及血清IL-2、7及NSE改变.docVIP

不同热性惊厥患儿脑脊液及血清IL-2、7及NSE改变[摘要] 目的 通过分析单纯型和复杂型热性惊厥（FS）患儿脑脊液及血清白细胞介素2（IL-2）、白细胞介素7（IL-7）和神经元特异性烯醇酶（NSE）的变化，探讨单纯型和复杂型热性惊厥（FS）发作后脑损伤与白细胞介素2（IL-2）、白细胞介素7（IL-7）和神经元特异性烯醇酶（NSE）的关系。方法 选取我院2008年1月～2011年1月住院治疗的22例单纯型FS、19例复杂型FS和20例发热而无惊厥患儿为研究对象，发热而无惊厥患儿为对照组。采用ELISA法对患儿的血清、脑脊液中IL-2、IL-7和NSE进行测定。结果 复杂型和单纯型FS组脑脊液IL-2、IL-7水平较对照组明显增高，差异有显著性（P＜0.01），复杂型FS组较单纯型FS组明显升高，差异具有显著性（P＜0.01）。结论 白细胞介素2（IL-2）、7（IL-7）和神经元特异性烯醇酶（NSE）水平与脑损伤程度有关。 [关键词] 热性惊厥；白细胞介素2；白细胞介素7；神经元特异性烯醇酶 [中图分类号] R725 [文献标识码] B [文章编号] 1673-9701（2011）31-21-02 The Levels of Cerebrospinal Fluid and Serum IL-2、IL-7 and NSE in Children with Simple and Complex Febrile Seizures DING Zhenyao GUO Aihong LI Hongwei Cangnan County Peoples Hospital of Wenzhou City，Zhejiang Province，Cangnan 325800，China [Abstract] Objective To evaluate the relationships of brain injury after febrile seizures and the levels of serum IL-2、IL-7 and NSE in children with simple and complex febrile convulsion from the changes of IL-2、IL-7 and NSE. Methods Twenty-two cases of simple FS，nineteen cases of complex FS and twenty cases of children with fever but without convulsions were selected in this study. Children with fever but without convulsions were control group. Children’s cerebrospinal fluid and serum IL-2、IL-7 and NSE were measured by ELISA. Results The levels of cerebrospinal fluid IL-2 and IL-7 in children with simple and complex febrile convulsion was significantly higher than those in control group. The difference was significant（P＜0.01）. The levels of cerebrospinal fluid IL-2 and IL-7 in children with simple febrile convulsion was significantly higher than complex febrile convulsion. The difference was significant（P＜0.01）. Conclusion The levels of IL-2、IL-7 and NSE in children had the relationship with the degree of brain injury. [Key words] Febrile seizures；IL-2；IL-7；NSE 热性惊厥（febrile sezures，FS）是小儿时期较常见的中枢神经系统功能异常的紧急症状，在婴幼儿更为多见，好发年龄为6个月～5岁，以9～20个月为高峰，发病率约为2%～4%。其发作的典型临床表现是：意识突然丧失，多伴有双眼球上翻，凝视或斜视，面肌或四肢肌强直、痉挛或不停地抽动。发作时间