两种药物联用对急性脑梗死患者神经功能及血液流变学影响探究.doc

两种药物联用对急性脑梗死患者神经功能及血液流变学影响探究[摘要]目的 观察依达拉奉联合奥扎格雷钠治疗急性脑梗死的疗效，探讨二者对急性脑梗死患者血液流变学各指标的影响。方法 50例急性脑梗死患者随机分为观察组（常规治疗+依达拉奉联合奥扎格雷钠）及对照组（常规治疗）各25例，观察两组治疗14d后的神经功能缺损评分的变化及两组治疗前后血液流变学指标全血黏度、血浆黏度、纤维蛋白原、刚性指数、红细胞压积的变化。结果 两组治疗14d后，两组患者的神经功能缺损评分比较均较治疗前明显降低，且观察组较对照组降低更明显（P＜0.05）。观察组治疗后全血黏度、血浆黏度、红细胞压积、纤维蛋白原和血小板聚集率等血液流变学指标均明显改善（P＜0.05）。而对照组上述指标无显著变化。结论 依达拉奉联合奥扎格雷钠治疗急性脑梗死具有较好的临床疗效，能明显改善患者的血液流变学变化，改善患者的神经功能，值得推广和应用。 [关键词] 急性脑梗死；奥扎格雷钠；依达拉奉；血液流变学 [中图分类号] R743.34 [文献标识码] A [文章编号] 1673-9701（2011）26-03-02 Effects of Two Drugs Together Treatment of the Patients with Acute Cerebral Infarction on the Nerve Function and Blood Rheology WANG Hongbo WANG Hong HU Zhixia Ningbo City Beilun District TCM Hospital，Ningbo 315800，China [Abstract] Objective To observe the effect of edaravone joint fasudil hydrochloride treatment acute cerebral infarction. Methods All 50 cases patients were randomly divided into observition group and control group，both groups were received conventional therapy. Observe in the conventional treatment given on the basis of edaravone and co-treatment of fasudil hydrochloride，and to compare the efficacy and neurological deficit score changes before and after treatment. Results Compared with the control group，the observation group efficiency were significantly higher than the control group （P＜0.05）. And after 14d treatment in both groups， two groups patients with neurological deficit scores were significantly lower than before treatment， and observation group were decreased more significantly （P＜0.05）. Conclusion Edaravone joint fasudil hydrochloride treatment acute cerebral infarction with a good clinical efficacy. [Key words] Acute stroke； Fasudil hydrochloride；Edaravone； Hemorheology 脑梗死后，缺血再灌注损伤是临床治疗的关键之一。缺血再灌注过程中脂质可产生许多高度反应性的氧自由基，导致脂质、蛋白质和核酸过氧化，细胞膜破坏。另外，血液流变学异常也是脑梗死发病及复发的主要原因之一，血液流变学的检测可作为临床上辅助诊断指标之一。依达拉奉是一种新型自由基清除剂，可以降低氧自由基的浓度，抑制脂质过氧化反应，稳定神经细胞膜 [1]，而奥扎格雷钠是一种血栓素合成酶抑制剂，能使血栓形成过程受到抑制 [2]。我院2008年1月～2011年1月应用依达拉奉联合奥扎格雷钠治疗急性脑梗死患者25例，效果较好，且二者联合应用对急性脑梗死患者的血液流变学