头孢哌酮钠-舒巴坦钠及5种常用输液配伍稳定性考察.docVIP

头孢哌酮钠/舒巴坦钠及5种常用输液配伍稳定性考察[摘要] 目的：考察头孢哌酮钠/舒巴坦钠与5种常用输液配伍的稳定性。方法：利用双波长分光光度法测定头孢哌酮钠/舒巴坦钠联合制剂中头孢哌酮钠和舒巴坦钠的含量，并对与5种常用输液配伍的稳定性进行初步考察。结果：头孢哌酮钠在2~20 mg/L范围内浓度与吸收度呈良好的线性关系，检测限为0.56 mg/L，平均回收率为99.77%，RSD为1.06%(n=9)。舒巴坦钠在2~20 mg/L范围内浓度与吸收度呈良好的线性关系，检测限为0.56 mg/L，平均回收率为99.86%，RSD为1.09%(n=9)。结论：临床上注射用头孢哌酮钠/舒巴坦钠在配制3 h内含量会有所下降，但变化不大，可与5种常用输液配伍使用，该实验可以为临床配伍提供一些参考。 [关键词] 头孢哌酮钠；舒巴坦钠；双波长分光光度法；配伍稳定性 [中图分类号]R913 [文献标识码]A [文章编号]1673-7210（2008）04（b）-040-03 Compatible stability of cefoperazone sodium/sulbactam sodium and five kinds of routine transfusion QIAN Yan-hua1, CAI Qi2 (1. Pharmacy Department, the First People′s Hospital of Kunming City, Kunming 650011, China; 2.Biological Room, Inspection Institute for Medical Instrument of Yunnan Province,Kunming 650034,China) [Abstract] Objective：To investigate the compatible stability of cefoperazone sodium/sulbactam sodium and five kinds of routine transfusion.Methods: The contents of cefoperazone sodium and sulbactam sodium in cefoperazone sodium/sulbactam sodium were determined by dual-wavelength spectrophotometry, and the compatible stability with five kinds of routine transfusion was investigated preliminarily. Results: The linear range of cefoperazone sodium was 2~20 mg/L, the detection limit was 0.56 mg/L, the average recovery was 99.77% with RSD of 1.06% (n=9). The linear range of sulbactam sodium was 2~20 mg/L, the detection limit was 0.56 mg/L, the average recovery was 99.86% with RSD of 1.09%(n=9).Conclusion:The content of cefoperazone sodium /sulbactam sodium will decrease in three hours,but the change is not significant.It can be compitable with five kinds of routine transfusion. [Key words] Cefoperazone sodium; Sulbactam sodium; Dual-wavelength spectrophotometry; Compatible stability 注射用头孢哌酮钠/舒巴坦钠（cefoperazone sodium and sulbactam sodium for injection）是由头孢哌酮钠和舒巴坦钠按1∶1或2∶1的比例组成的广谱抗生素制剂，通过抑制细菌细胞壁合成达到杀菌作用。舒巴坦钠对耐药菌株产生的β-内酰胺酶有抑制作用，与头孢哌酮钠联用具有协同作用，治疗细菌性感染具有明显的效果，有效率达90%以上，在国内外研究中都取得了满意的结果[1]。头孢哌酮、头孢哌酮钠、舒巴坦钠及头孢哌酮钠/舒巴坦钠