急性心肌梗死（AMI）.ppt

Comparison of Plasma Cardiac Troponins T an I in Chronically Hemodialyzed Patients in Relation to Cardiac Status and Age;WHO 急性心肌梗塞（AMI）的黃金準則 ;WHO 準則的缺點;中华医生网收集/;有用的心臟標記;中华医生网收集/;AMI 血清標記;中华医生网收集/;Troponins Complex; SUMMARY ?Introduction ?Patients ?Materials and Methods ?Results ?Discussion ; Introduction ;Abbreviations: AMI, acute myocardial infarction CHD,coronary heart disease CRF, chronic renal failure cTnI, cardiac troponin I cTnT, cardiac troponin T hs CRP, high sensitivity C-reactive protein Stratus CS, Stratus Cardiac System URL, upper reference limit ; Patients The mean age of the patients was 60.1±14.8 years (range: 23–88 years) The length of dialysis averaged 7.2 years (SD: 7.1, range: 1–30 years) 49位 patients----------CHD(+)group 48位patients-----------CHD(-)group n=97 CRF patients ; Sample Collected The patients were followed during a period of 9 months and blood samples were taken at 3-month intervals (T1, T2, T3 andT4) Samples were obtained before the first dialysis of the week to avoid possible changes in troponin levels during dialysis Venous blood was collected immediately before dialysis and tubes were centrifuged (5 min at 1000 × g) upon arrival in the laboratory; cTnT cTnT was determined by third generation immunoassay Using Elecsys analyzer (Roche Diagnostics,Mannheim,Germany) Sample tube------EDTA-plasma Principle: This assay uses two monoclonal antibodies specifically directed against human cTnT;