4-溴-5-（4-甲氧苯基）-3-（甲氨基）-呋喃酮对聚氯乙烯上细菌生物膜的影响.pdfVIP

生物医学T程与临床2008年1月第12卷第1期 BME＆ClinMed，January 2008，Vo1．12，No．1 — 5 一 基础研究· 4一溴一5一(4一甲氧苯基)一3一(甲氨基)一呋喃酮 对聚氯乙烯上细菌生物膜的影响 许 赓 ，黄云超 ，叶联华 ，李振龙 摘 要：目的 观察4一溴一5一(4一甲氧苯基)一3一(甲氨基)一呋喃酮对聚氯乙烯表面表皮葡萄球菌形成的影响。方法 用 4一溴一5一(4一甲氧苯基)一3一(甲氨基)一呋喃酮覆盖在聚氯乙烯表面，通过体外生物膜形成实验，观察4一溴一5一(4一甲氧苯 基)一3一(甲氨基)一呋喃酮对表皮葡萄球菌生物膜形成的影响。结果 经4一溴一5一(4一甲氧苯基)一3一(甲氨基)一呋喃酮处 理过的聚氯乙烯表面表皮葡萄球菌生物膜厚度和菌落数量少于对照组(P0．05)。结论 4一溴一5一(4一甲氧苯基)一3一(甲 氨基)一呋喃酮抑制聚氯乙烯上表皮葡萄球菌生物膜的形成。 关键词：生物材料：细菌生物膜：溴代呋喃酮 中图分类号：R3l8 文献标识码：A 文章编号：1009—7090(2o08)01-0005—04 Influence of 4一bromo一5一(4一methoxypheny1)一3-(methylamino)一2(5H)一furanone to the biofilm formation on the PVC material XU Geng ，HUANG Yun—chao2,YE Lian—hua ，LI Zhen—long’ (1．Department of Thoracocardiac Surgery，Heze MunicipalHospitd，Heze 274031，Shandong，China；2．The Affiliated ThirdHospital，KunmingMedical College， Kunming 650106，Yunnan，China) Abstract：0bjective To investigate the influence of 4一bmmo一5一(4一methoxypheny1)-3一(methylamino)一2(5H)-furanone to the biofilm formation of Staphylococcus epidermidis(SE)on the surface of PVC materia1．Methods The 4一bromo一5一(4一 methoxypheny1)一3一(methylamino)一2(5H)一furanone was coated on the surface of PVC material，then the in vitro experiment of biofilm formation was performed and the influenee of 4一bromo一5一(4～methoxypheny1)一3一(methylamino)一2(5H)-furanone to the biofilm formation of Staphylococcus epidermidis was observed．Results The depth and the density of the biofilms were obviously decreased on the surface of the PVC material coated with 4一bromo一5一(4一methoxypheny1)一3一(methylamino)一2(5H)一 furanone compared with those in the control group (P0．05)．Conclusion It iS demonstrated that the 4一bromo一5一(4一 methoxypheny1)一3-(methylamino)一2(5H)-furanone could inhibit the biofilm format