5-HT1B基因A161T多态性与抑郁症的关联研究.pdfVIP

· l6· Archives of Psychiatry．20o8．V01．20．No．1 · 论著 · 5-HT1B基因A161T多态性与 抑郁症的关联研究 刘志芬 孙 燕 任 燕 段慧君 罗锦秀 付文媛 李素萍 张克让 【摘要】 目的 探讨抑郁症患者与5-HTIB受体基因A161T多态性之间的关系。方法 应用聚合 酶链式反应(PCR)扩增技术及限制性片段长度多态性(RrLP)分别检测365例抑郁症患者(病例组)、 365名健康人(对照组)的5．HTIB受体基因A161T多态性。结果 5．HT1B受体基因A161T多态性在 病例组和对照组的基因型和等位基因分布频率无显著性差异；按照发病年龄(30岁为界)、有无家族史 及有无自杀观念分层后，各亚组与对照组问基因型和等位基因分布也无显著性差异。经多因素分析控 制年龄、性别因素后各组基因型分布仍无显著性差异。结论 5-HT1B受体基因A161T多态性可能不是 抑郁症及其各临床亚型发病的一个危险因素。 【关键词】抑郁症 5-HT1B受体基因 多态性 关联 Associalion analysis between the 5-HTIB receptor gene A161T polymorphism and major depression in Hall nationality of China North L／u n，Sun Yan，Ren Yan，Dlg~rg Huijun，Luo Jingxiu，几 Wenyuan， Li Suping，Zhang Kerang．Department ofpsychiatry，The First Hospital ofShanxi Medical University，Taiyuan， Shanxi O3O0o1 【Abstract】 Objective：To investigate the association between 5·HT1B receptor gene A161T polymorphism and major depression in Han nationality of China North．Methods：The polymorphism of5-HT1B A161T of 365 major depression patients(patient group)and 365 controls(control group)had been genotyped using the polymerase chain reaction and restriction fragment length polymorphisms(PCR—Rr~P)technique． Results：No significant difference was observed between the patients and control subjects in the genotype distributions and allele frequencies for the investigated A161T polymorphisms．Similarly，no significant differences were found between more homogeneous subgroups of patients and control subjects．Conclusion：This study suggests that the investigated polymorphisms in the 5·HT1B gene are not major risk factors in increasing susceptibility to either major depression or its clinical subtypes in a Han Chinese population． 【Key words】 Major depression 5-HT1 B receptor gene Polymorphism Association 抑郁症是一种遗传度较高的疾病，国内外研究 该基因与抑郁症关系的研究