乳腺波谱2010.12课件.ppt

乳腺1H-MRS; Overview;MRS is a noninvasive study living organ, tissue metabolism, quantitative analysis of biochemical changes in the methods and compounds.;Can reflect the metabolic situation of organization at the molecular level. ;MRS is an important aspect of quantitative analysis of metabolites. MRS的一个重要方面是可以对代谢产物进行定量分析。; Can make use of peak height (representing the resonance signal intensity) and width (on behalf of the resonance frequency) calculated the area under the peak.可利用波峰的高度（代表共振信号强度）和宽度（代表共振频率）计算波峰下面积。;The area under the metabolite peak measured with the proportional content of the metabolites. 各代谢产物的波峰下面积与所测的代谢产物的含量成正比。;MRS including both 1p-MRS and 1H-MRS.;1H-Spectrum Peak;Spectrum detected is not fixed within the choline in the cell membrane, but the film conversion process in the water-soluble components, mainly soluble choline compounds。波谱检测到的不是固定在细胞膜内的胆碱，而是膜转换过程中的水溶性成分，主要是可溶解的胆碱化合物。;Cho wave increased explain update to speed up the cell membrane, cell density, usually due to tumor cell proliferation. Cho波增高说明细胞膜更新加快、细胞密度大，通常为肿瘤细胞增殖所致。;breast 1H-MRS measurements Cho of tissue main content. 乳腺1H-MRS主要测量组织内Cho的含量。 Cho and its metabolites was determined from the mammary epithelial cell metabolism, mainly involved in membrane transport and diffusion functions. Cho及其代谢物的含量决定于乳腺上皮细胞的代谢水平，主要是参与细胞膜运输及扩散功能。;As the active metabolite of free Cho levels in normal tissues in the lower, Cho concentration reflects increased membrane synthesis or cell proliferation accelerated. 作为活性代谢物的游离Cho在正常组织中存在浓度较低，Cho含量升高反映细胞膜合成增加或细胞增殖的加快。;Proliferative cancer cells, rapid cell division leading to cell proliferation and increase in speed and membrane transport, Cho content also will be increased. Similarly, if benign tumors grow rapidly in the short term, Cho levels can be increased.恶性肿瘤细胞增殖旺盛，快速的细胞分裂导致细胞增殖加快和膜转运增加，Cho含量也随之升高。同样，良性肿瘤若在短期内迅速生长，Cho含量也可升高。;Lip wave （脂质峰）: wave Peak （波峰）at 1.4ppm Breast have big fat content, lipid peak apparent 乳腺脂肪含量大，出现明显脂质峰;Reported