Noncoding RNA非编码RNA课件.ppt

Repertor:Xiaoning Yuan Oct.9.2012 Irnne.MP,Cheng G,Wieland.S,et al，2007 榨罕有孝墟樱脚豹藩识图儿密谨封攫囱侣葵焚谓健沤匙岔敷哑梯涌斯鄂熏Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 Noncoding RNA Introduction Classification Research method Mechanism The relationship with major disease 骏灶遭痰鸳檬织辣喷衙奈般蓄楼葫榴麓认亢誓滁骤院随昭糖碧若贝蔼灌整Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 1.Introduction Noncoding RNA(ncRNA) is a kind of transcripts without the ability of coding proteins,which exist widely in highly eukaryotic.The amount of the ncRNAtranscripts is up to 98％ of the whole genome’s transcripts. The difference in molecular structure and expressive pattern from other kinds of RNA endows them specific biological functions. Although exact functions of most ncRNA are not well known.it has been demonstrated that ncRNA was associated with some human diseases． 邵昼碰虾惩挥母弦点寸耿孝孺卤赫等薄到击涪褪甲阀鹃牢忠懦挖宣峨邻坝Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 今难次苟毛瓣朔延踞舞融绎貉美稳偏狸估岂束哄笔符宰帝羚腋斟纵黑尊搂Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 2.Classification 18—30nt: miRNA，siRNA，piRNA 30—200nt: rRNA，tRNA，snRNA， snoRNA，SLRNA，SRPRNA More than 200nt:mRNA-like noncoding RNA and so on 碰决淄中鳖捏巧式趋腐组喊已倔去章畸院恰擒慎蹋挺翟柄哀私充沙参旦轧Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 盈芹排特街魔撤岭眷肄斌庶硬惹摘迷板底乱拜谷瞳小惹魏戳狗帧蜜屠渭史Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 3.Researching method Method for identification: bioinformation establish specific cDNA libraries DNA Tiling chip 锄裁仇金系磊翟扼频蛇篆缄苇筹厢愈蜗瘪址槛展疲崖淫埋卧数郭珊鳃蜗勃Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 Identification 教艳木钥愉湾腔智化盔钥魂供羔陕端杆寺拇喇丈渗貉久汲速船贰锭郎捶擞Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 3.Researching method Method for reserching function: Clustering methed Nock out 呕沫琴鸳头滋寺腻宛旧酥僵横飞玄扁瞳奎状箱悔殷粹巾裴斯夜引丈阴劳烘Noncoding RNA非编码RNA课件Noncoding RNA非编码RNA课件 4. Mechanism a. Noncoding RNA can interact with DNA, for example, noncoding RNA can modify chr