- 1、本文档共74页,可阅读全部内容。
- 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
Primary afferent neurons of the gut课件
Primary afferent neurons of the gut
(消化道初级感觉神经元)
Function:
Monitoring and control of the digestive system, including:
Generating appropriate reflex response to the gut lumen contents
Participates in reflexes between organs
Convey signals from digestive organs to the CNS –
Trigger reflex
Co-ordination with other body system
Relate to sensation including discomfort, nausea, pain and satiety;intrinsic and extrinsic
内源性和外源性;Intrinsic primary afferent neurons, IPANs, within ENS;I Intrinsic Primary Afferent Neurons and
Nerve Circuits within the Intestine;Types of neurons that form enteric nerve circuits
According to the
functions,
key transmitters
projections to targets
;LM: longitudinal muscle; MP: myenteric plexus; CM: circular muscle; SM: submucosal plexus; Muc: mucosa. ;LM: longitudinal muscle; MP: myenteric plexus; CM: circular muscle; SM: submucosal plexus; Muc: mucosa;2. Characteristics of intrinsic primary afferent neurons (IPANs);2. Characteristics of IPANs- Conti;2. Characteristics of intrinsic afferent neurons- Conti;2. Characteristics of IPANs- Conti;Mucosal mechanoreceptors:
Puffs of nitrogen gas on the mucosal induce C-Fos expression in IPAN
Blocked by TTX
Unaffected by hexamethonium (六甲铵), the nicotinic receptor antagonist
Mostly indirect, through the release of 5-HT from enterochromaffin cells (肠嗜铬细胞) in the mucous membrane (粘膜);3. Enteric nerve circuits
Intrinsic reflexes that affect motility, water and electrolyte secretion and blood flow all occur in the intestine
Circuits for motility control;Secretomotor and vasomotor reflexes;II Extrinsic Primary Afferent Neurons
The rich sensory innervation (神经支配) of the gastrointestinal tract comprise:
Intrinsic sensory neurons contained entirely within the gastrointestinal wall
Intestinofugal fibres 肠离心神经纤维 that project to prevertebral ganglia (椎前神经节)
Vagal and spinal afferent that projects to the central nervous system. ;埃妥拒钧餐靖挝品鸦抒统台奈家冶暗拨业薪砾幻热镭汕雍囤扳喉歼豺碱打Primary afferent neurons of the gut课件Primary afferent
文档评论(0)