BRCC36的生物学功能及在心血管疾病中的研究进展_朱华江.pdf

()2015 1 9 2 Chin J Clinicians(Electronic Edition),January 15,2015,Vol.9,No.2 273 BRCC36 BRCC362003BRCC DNA BRCC36 DNA BRCC36 Biological functions and progress in cardiovascular diseases of BRCC36 Zhu Huajiang, Gong Kaizheng, Zhang Zhengang. Department of Cardiology, the Second Clinical Medical College of Yangzhou University, Yangzhou 225001, China Corresponding author: Gong Kaizheng, Email: yungkzh@163.com Abstract BRCC36 is a subunit found form BRCC complex in 2003, which participates in various kinds of physiological processes, such as the regulation of the activity of the proteasome, DNA damage repair, cell signal transduction and cell cycle control. It plays an important role in cancer, angiogenesis and myocardial protection. The paper presented a review of the structure and function of BRCC36, and it’s progress of research on cardiovascular disease. Key words DNA repair; Heart disease; BRCC36; Deubiquitination BRCC36 BRCA1-BRCA2 containing complex subunit 3 2003 BRCC BRCA1- DNA BRCA2-containing complex JAMM Jab1/MPN/ Mov34 metalloprotease/MPNMpr1/Pad1 N-terminal BRCC36 [1-2]JAMM/MPN BRCC36 POH1CSN5 BRCC36 AMSH AMSH-LP BRCC36 BRCC36 POH1CSN526S BRCC36BRCC3 [5] COP9JAMM X28Xq28 316 36 kDa[1] AMSHAMSH-LP BRCC36Pohl/PadlCOP9 CSN5/Jabl MPN [3] BRCC36 BRCC36 BRCC BRCC36 BRCA1-BRCA2-containing complexAbraxas BRCC36 BRISCBRCC36 contai