2014年1月药物化学考查课试题及答案（Examination questions and answers for the course of medicinal chemistry examination in January 2014）.doc

2014年1月药物化学考查课试题及答案（Examination questions and answers for the course of medicinal chemistry examination in January 2014） BDCEB DABBA BCAAA CACDA The 1 refers to the structure and biology necessary metabolites can occur similar competitive reaction with specific enzymes in normal metabolic pathways, thus impeding the enzyme function, metabolism of substances interference. 2 refers to the molecular structure of main elements with three-dimensional space properties of a receptor ligand based on molecular recognition. The 3 refers to some pharmacologically active compounds, but these compounds in vivo after metabolic biotransformation is converted to active drug. 4 in vivo absorption, distribution, metabolism and excretion of the drug groups involved in itself does not have significant biological activity, pharmacokinetic properties only drugs 5 is a clear pharmacological activity of a target and model of the newly discovered compounds. 1 estradiol by estrogen in the treatment of skin absorption agent. To supplement the female ovarian secretion of 17- beta estradiol, while avoiding the side effects caused by oral (breast pain, weight gain, hypertension, gallstones and abnormal liver function). Estrogen can promote cell synthesis of various DNA, RNA and the corresponding tissue in different proteins. The main source of estrogen in thecal cells and granulosa cells. In the follicular development process, first by LH stimulation of thecal testosterone secretion by granulosa cells, under the stimulation of FSH into estradiol, namely double double mode of action of gonadotropin cells. In addition, adrenal cortex, placenta and testis have secretion of male animal. Here is the definition of estrogen estradiol, ovarian failure after a sharp decline in estradiol induced menopause syndrome and estradiol deficiency disease. Estradiol (o) estradiol C18H24O2 is a steroidal estrogen. There are two types of alpha, beta, alpha type physiological effect. Winter Steiner (Wintersteiner et