ards激素冲击是否奏效（Does ARDS hormone shock work）.doc

ards激素冲击是否奏效（Does ARDS hormone shock work） ARDS: does hormone shock work? 2011-03-01 Qian Guisheng Acute lung injury or acute respiratory distress syndrome (ALI/ARDS) is an acute, progressive respiratory failure caused by a variety of pulmonary and respiratory factors other than cardiogenic origin. Alveolar capillary membrane damage caused by uncontrolled inflammatory response of lung cells (such as neutrophils and macrophages) is the pathological basis for the formation of pulmonary capillary permeability. At present, scholars at home and abroad are trying to treat the main pathogenesis of systemic inflammatory response, in order to reduce lung and systemic inflammation, and achieve the purpose of treatment of ARDS. Adrenocortical hormone (hormone) has broad pharmacological effects, multiple pathogenesis can be applied to ALI or ARDS, which is very early for the treatment of ALI or ARDS, but there is no consensus of hormone therapy for ARDS, one of the hot research is still ARDS. In this paper, the domestic and international research progress, mainly on ARDS hormone impact is briefly described. Since the concept of adult respiratory distress syndrome was proposed by Ashbaugh et al in 1967, hormone has been widely used in clinical treatment of ARDS. One view is that the pathological basis of ARDS is increased and alveolar capillary membrane permeability, the hormone can effectively improve alveolar - capillary membrane permeability, reduce capillary permeability, achieve the purpose of treatment of ARDS. Sibbald in 19 patients with bacterial infection caused by ARDS, serum albumin was labeled with I131, and albumin content in bronchial secretions was determined. Given large doses of hormone treatment, the content of albumin in 14 cases of bronchial secretions in survivors in rapid decline, while 5 cases of patients with bronchial secretions died within 24 hours of the albumin content did not decrease significantly. These results indicate that ARDS patients do have m