15—美抒玉治疗抑郁症睡眠障碍多导睡眠图变化.docVIP

美抒玉治疗抑郁症睡眠障碍多导睡眠图变化 宋雪祥 王国祥 赵彦平 目的：探讨抑郁症合并睡眠障碍患者多导睡眠图特点，并与正常人比较，探讨药物美抒玉治疗效果及多导睡眠图变化。材料及方法：用polysmith型多导睡眠图，对21名抑郁症合并睡眠障碍患者及10名正常对照者进行测定，抑郁症患者美抒玉治疗2月后复查多导睡眠图，并进行治疗前后精神量表测定。测量数据以ｘ±ｓDepartment of Neurology, Peoples Hospital of Yixing City, Yixing 214200) Purpose: To explore the varieties of polysomnography in patients with depression in comparison with normal people; To assess the effects and varieties of polysomnography with trazodone. Methods: Polysmith polysomnography was performed on 21 insomnia patients with depression and 10 normal people. Insomnia patients with depression were cared with trazodone and polysomnography was examined two months later. Rating scales for mental health were investigated before and after trazodone cares. Data was measured by ｘ±ｓResults: Wake after sleep onset、REM sleep in insomnia patients with depression were longer than those in controls and had significant difference; Compared with total sleep timeleep efficiency index、REM latency NREM slow-wave sleep, insomnia patients with depression were lower. After trazodone cared, there were significant longer in total sleep time、sleep efficiency index、NREM slow-wave sleep. While wake after sleep onset was obvious lower and self-rating depression scale was better. Conclusions: Trazodone is effective in the treatment of antidepressant-associated insomnia and is good to abnormal night physiological signals on polysomnography. Zopidem caused an improvement in subjective and objective sleep quality. Key words: polysomnography(PSG) sleep disorders depression trazodone 随着社会的发展，生活节奏的加快，抑郁症发生率有上升的趋势，其中相当一部分患者突出表现为睡眠障碍，现将2005年3月~2006年5月在我院神经科门诊因睡眠障碍而就诊的抑郁症患者21名行多导睡眠图检查，美抒玉治疗后进行复查，结果如下。 对象与方法 一、研究对象符合CCMD-2-R失眠症的断标准。排除酒、男名，女1名；年龄30～5岁，平均3.6岁病程～年，平均.6年。男性名，女性名；年龄0～岁，平均3.6岁±标准差(ｘ±ｓｘ±ｓ451.6±37.2 448.7±48.2 412.2±34.8 总睡眠时间(min) 350.3±29.6★ 392.6±27.4▲ 379.9±31.7 睡眠效率(%) 0.74±0.02★★ 0.86±0.3▲ 0.92 ±0.01 睡眠潜伏期(min) 19.8±5.7