合成香料环己氧基乙酸烯丙酯和异戊氧基乙酸烯丙酯.pdf

Jan. 2007 现代化工 27 1 # 42 # Modern Chemical Industry 2007 1 合成香料环己氧基乙酸烯丙酯和 异戊氧基乙酸烯丙酯的新方法 1 2 3 金 欣, 贾卫民, 杨锦宗 ( 1. 青岛科技大学化工学院, 山东 青岛266042; 2. 厦门集美灌口涌泉集团有限公司, 福建厦门361023; 3. 大连理工大学精细化工国 重点实验室, 辽宁大连116012) : Williamson (EDA) O) H , , 83% 79% : ; ; ;O ) H :TQ22 124 :A : 02 3- 4320( 2007) 01- 0042- 04 A novel process for synthesis of flavor allyl cyclohexoxyacetate and allyl amyl glycolate 1 2 3 JIN X in , JIA Wei-min , YANG Jin-z ong ( 1. College of Chemical Engineering, Qingdao University of Science andTechnology, Qingdao 266042, China; 2. Postdoctoral Research Workstation, Yongquan Group Co. , Ltd. , Xiamen 361023, China; 3. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China) Abstract: This study provided a more facile process in place of Williamson reaction for the synthesis of flavor allyl cyclohexoxyacetate and allyl amyl glycolate. Ethyl diazoacetate ( EDA) undergoes a facile bis ( salicylaldehydato) copper carbenoid mediated O) H insertion reactionwith cyclohexanol and isoamyl alcohol to afford ethyl 2-cyclohexyloxy-acetate ( Ñ) and ethyl 2-( 3-methyl-2-butyloxy)-acetate ( Ò) .These compounds were used as synthetic precursor for title compounds. The effects of catalyst, reaction temperature as well as the ratio of alcohol and EDA on insertion yield were discussed. Under optimized reaction conditions the compounds ( Ñ) and ( Ò) were respectively obtained in an 83% and a 79% reaction yield. Key words: allyl cyclohexoxyacetate; allyl amyl glycolat