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Journal of Cardiothoracic Surgery BioMed Central Research article Open Access Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia Georgios T Karapanagiotidis*, Polychronis Antonitsis, Nicholas Charokopos, Christophoros N Foroulis, Kyriakos Anastasiadis, Efthymia Rouska, Helena Argiriadou, Kyriakos Rammos and Christos Papakonstantinou Address: Department of Thoracic and Cardiovascular Surgery, AHEPA University Hospital, Thessaloniki, Greece Email: Georgios T Karapanagiotidis* - karapang7@; Polychronis Antonitsis - antonits@otenet.gr; Nicholas Charokopos - charokoposnick@; Christophoros N Foroulis - cforoulis@otenet.gr; Kyriakos Anastasiadis - anastasiadisk@; Efthymia Rouska - rouskamed@; Helena Argiriadou - argiriadou@; Kyriakos Rammos - rammos@the.forthnet.gr; Christos Papakonstantinou - papakon@med.auth.gr * Corresponding author Published: 3 November 2009 Received: 25 July 2009 Accepted: 3 November 2009 Journal of Cardio thoracic Surgery 2009, 4:59 doi:10.1186/1749-8090-4-59 This article is available from: /content/4/1/59 © 2009 Karapanagiotidis et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Matrix metalloproteinases (MMPs) constitute a family of zinc-dependent proteases (endopeptidases) whose catalytic action is the degradation of the extracellular matrix components. In addition, they play the major role in th