磷脂爬行酶1.pdfVIP

Acta Physiologica Sinica , December 25, 2006, 58 (6): 501-510 501 Brief Review Phospholipid scramblase 1 1,2 1 1,2,* HUANG Ying , ZHAO Qian , CHEN Guo-Qiang 1Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiaotong University School of Medicine; 2Institute of Health Science, Shanghai Jiaotong University School of Medicine/Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China Abstract: Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import into the nucleus, where it binds to genomic DNA. Although the original work showed that PLSCR1 contributes to the transbilayer movement of phospholipids, the following studies revealed that PLSCR1 expression can be induced by some cytokines such as interferon, epidermal growth factor, and also by leukemic cell differentiation- inducing agents such as all-trans retinoic acid (ATRA) and phorbol 12-myristate 13-acetate (PMA). PLSCR1 was also shown to interact with several protein kinases including c-Abl, c-Src, protein kinase Cδ as well as some other proteins such as onzin, suggesting the roles of PLSCR1 in cell signaling. Indeed, the current evidence proposes that PLSCR1 contributes to cell proliferation, differentiation, apoptosis, and plays roles in the pathogenesis of cancers, especially leukemia. Key words: phospholipid scramblase 1; leukemia 磷脂爬行酶 1 1,2 1 1,2,* 黄 莹 ，赵 倩 ，陈国强 1 2 上海交通大学医学院病理生理学教研室，细胞分化与凋亡教育部重点实验室； 上海交通大学医学院/ 中国科学院上海生 命科学研究院健康科学研究所，上海 200025 摘 要：磷脂爬行酶1 (phospholipid scramblase 1, PLSCR1)属于Ca2+ 结合的棕榈酰化II 型膜蛋白，而非棕榈酰化