大豆肽与基因的相互作用.ppt

Genomic Imprinting Prader-Willi Syndrome - Maternal Imprinting of 15q11-13 Angelman Syndrome - Paternal Imprinting of 15q11-13 Chromosome 15q11-13 Deletion Thompson, McInnes, and Willard, Genetics in Medicine, 5th Ed., WB Saunders Co.1991, p.94. Patient with Prader-Willi Syndrome Molecular Causes of PWS Nicholis et al., TIG, 14(1998)194. Angelman syndrome epilepsy, Tremors a perpetually smiling facial expression. 70% have maternally-derived deletion of 15q12 2% have patUPD15 Molecular Causes of AS Gene Imprinting Balanced Deletion UPD Mutation Mutation Translocation Nicholis et al., TIG, 14(1998)194. 进一步研究的方向 是不是部分儿童的膳食和成年饮食促进现阶段美国糖尿病的流行？或这种流行与母体营养和积累的多代有关？ 导致后代葡萄糖或HCY水平持续增高的母体效应可能对后代健康产生长期的影响。其中的一些影响（特别是高血糖）可能会传递给将来的后代。 在早期发育阶段，鉴定出可能的、众多的、能引起长期健康问题和多代效应的条件至关重要。同时也需要这些早期事件的标志物。转录组学，表观基因组学和其它组学技术有助于发现这些标志物及相关机制。 设计合理的母体营养在阻止糖尿病代间传递，改善记忆力和认知能力，抑制有害等位基因等方面有巨大的潜力。 * Nucleosome and histone modifications. Each nucleosome comprises an octamer of histone molecules and double-stranded DNA. The amino termini of histones, which are called histone tails, can be post-translationally modified and function as signal integration platforms. The main epigenetic modifications at histone tail sites are: lysine and arginine methylation (MetK and MetR, respectively), phosphorylation (P), acetylation (Ac), and ubiquitination (Ub). * * * 母体营养与表观遗传学效应 qiming_14618@ Ming Qi 祁鸣, PhD, FACMG HUGO Lecturer CAP Inspector Center for Genetic Genomic Medicine James Watson Institute of Genomic Sciences Medical School of Zhejiang University BGI-Shenzhen Department of Pathology and Lab. Med. University of Rochester Medical Center Office：ZJU Med School A-713 现代医学导论－2013食品安全与营养专业求是科学班 营养基因组学模块 2015-04-15 References Textbook: 《营养基因组学：发现通往个性化营养的途径》第10章， Jim Kaput，Raymond L.Rodriguez. 祁鸣，朱心强等（译）：浙江大学出版社　2011 Your Diet Affects Your Grandchildrens DNA You are what you eat, the