结直肠癌化疗（Colorectal cancer chemotherapy）.doc

结直肠癌化疗（Colorectal cancer chemotherapy） colorectal cancer With the improvement of living standard, the incidence of CRC in China is increasing by 4.2% at an average annual rate of [1], which seriously threatens the life and health of the people. The accepted treatment for colorectal cancer is the first comprehensive treatment of surgery. Adjuvant chemotherapy is an important part of comprehensive treatment, but also the main means to prevent distant metastasis. However, the therapeutic role of chemotherapy in colorectal cancer has been suspected for a long time. In recent years, with the development of modern pharmacology and modern molecular biology, the status of adjuvant chemotherapy in colorectal cancer is gradually increasing. Currently, adjuvant chemotherapy for colorectal cancer has become one of the most active fields of tumor clinical research. I. The history of adjuvant chemotherapy for colorectal cancer Adjuvant chemotherapy for colorectal cancer in 1950s, after nearly 30 years of exploration, controversy, until 1988, Buyse [2] published the first effective adjuvant chemotherapy for colorectal cancer: a meta analysis report (Meta), the effectiveness of adjuvant chemotherapy for colorectal cancer to reach consensus. Over the past 10 years, many scholars devoted to the design of the development of new drugs and new adjuvant chemotherapy for colorectal cancer, and conducted a series of large-scale clinical study of adjuvant chemotherapy for colorectal cancer and has made great progress, and gradually changed peoples traditional ideas. Two 、 new concept of adjuvant chemotherapy for colorectal cancer (1) the concept of biochemical regulation (biochemical, modulation) of 5-Fu; Various data show that 5-Fu+ (leucovorin) is the most effective combination, and has been regarded as the standard treatment for CRC in the world, [3] (CF). (two) new concepts of 5-Fu administration 1, 5-Fu small dose long-term continuous perfusion (PVI) therapy 2, 5-Fu Chrono therapy Chro