地鼠保护力试验检测流行性出血热疫苗的效力研究.pdf

1997 25 4 34 地鼠保护力试验检测流行性出 血热疫苗的效力研究 董关木　刘文雪　杨立宏　安　祺　姚智慧　俞永新 ( 中国药品生物制品检定所, 北京　100050) 郝富勇　王晓宏　韩　亮　黄永成 ( 卫生部长春生物制品研究所, 长春　130062) , , EH F 374. 32 R Study of Protective Ability of HFRSVaccine with HamsterModelD ong Guanm u et al . N at ional I nst i- tute f or the Control of P har maceut ical and biolog ical P r od ucts, B e ij ing 100050 AbstractIt w as show n in our st udy t hat the ham sler is su sceptible to hem or rhag ic ever w ith r e- na l syndro m ( HF RS) . We o bser ved the pro tectiv e ability o 4 t ypes v accine o HFR S made in China and K or ea w ith ham ster model by challeng ing vir u s and com par ison w it h t heir ability o pro ducing nutr iliz- ing antibo dy . T he result pr oved that this 4 type vaccine pr ot ect ive r ate lev el ar e higher than their nutr il- izing antibody tit er. It is sho w n that pr otective ability test is much mo re repr esent the v accine qualit y lev el . ey words V accine o HF RS Go ld ham ster Pr otective T est N utr ilizing a ntibody 50 , 1 , , 1. 1 1 ( ) 19 81 Z 10 , , , 94 605 ( ) , L 99 , 94080 1- 7 L R1 ( ) , 94001