小型猪动脉粥样硬化模型构建思路-王双,杨关林.pdf

第 1 7 卷 第 6 期 辽宁中医药大学学报 Vol. 17 No. 6 2015 年 6 月 JOURNAL OF LIAONING UNIVERSITY OF TCM Jun .，2015 DOI：10.13194/j.issn.1673-842x.2015.06.026 小型猪动脉粥样硬化模型构建思路 王双，指导：杨关林 （辽宁中医药大学，辽宁 沈阳 110847 ） 通过文献查阅和对动脉粥样硬化动物模型的研究现状进行分析，我们发现国内外已有大量关于动脉粥 摘 要： 样硬化动物模型的研究。但各个模型的造模因素均存在很大差异，给模型的复制带来了很大困难。小型猪由于生 理特点及发病过程与人类相似，已被广泛用于制备动脉粥样硬化模型的研究。同时采取复合因素造成动脉粥样硬 化病变的造模方法已经成为被更多学者所认同的趋势。其中以高脂饲喂和球囊损伤两种方法为主。该文通过造模 动物、饲料配方、介入手术等方面为小型猪动脉粥样硬化模型提供构建思路。 关键词：动脉粥样硬化；小型猪；动物模型；构建思路 ( ) 中图分类号：R541.4 文献标志码：A 文章编号：1673-842X 2015 06- 0078- 03 Construction Idea of Swine Model of Atherosclerosis WANG Shuang，Advisor：YANG Guanlin （Liaoning University of Traditional Chinese Medicine，Shenyang 110847，Liaoning，China） Abstract：Through literature review and analyzing the research status of animal models of atherosclerosis（AS），we found that both at home and abroad have a lot of research on animal models of AS. However，the building factors of each model had significant differences，which brings great difficulty to the model replication. Due to the similarity of swine and human in physiological structure and pathological characteristics，swine have been widely used as the animal model of AS. Meanwhile，the modeling method which built by compound factors that cause AS has become a trend of identity by more scholars. High- cholesterol diet and balloon injury are the main modeling methods. In this article，we provide a construction idea of swine model of AS in the following aspects：animals，feed formula，interventional sugery，etc. Key words：at