ztc1＋1用于养阴清肺糖浆水提液的絮凝工艺研究-天津中草药杂志社.pdf

·478 · 中草药 Chinese Traditional and Herbal Drugs 第 42 卷 第 3 期 2011 年 3 月 ZTC 1 ＋1 用于养阴清肺糖浆水提液的絮凝工艺研究 1, 2 1 1* 孙 姣 ，孙泽沾 ，康 勇 1. 天津大学化工学院，天津 300072 2. 河北工业大学化工学院，天津 300130 摘 要：目的 优化养阴清肺糖浆的生产工艺，更好地保留有效成分，提高药液的澄清度。方法 采用天然高分子絮凝剂 ZTC 1 ＋1 对养阴清肺糖浆原药水提液进行絮凝处理，以有效成分甘草酸保留率和药液浊度为衡量指标，考察絮凝剂用量、 絮凝温度、搅拌速度、搅拌时间对絮凝效果的影响，并将絮凝后的药液离心处理，以确定最佳工艺条件。结果 最佳絮凝提 纯工艺条件为药液温度 30 ℃，ZTC 1 ＋1 用量 0.6 g/L，快搅速度450 r/min ，快搅时间2 min ，慢搅速度 50 r/min，慢搅时间 10 min，絮凝后的药液再在转速 3 000 r/min 下离心 20 min ，此时甘草酸保留率为 84%，药液浊度只有 1.3 NTU。结论 ZTC 1＋1 用于养阴清肺糖浆原药水提液的絮凝提纯效果明显优于醇沉法，絮凝法可以替代醇沉法用于养阴清肺糖浆水提液的提纯。 关键词：养阴清肺糖浆；水提液；ZTC 1 ＋1；絮凝；浊度；保留率 中图分类号：R284.2 ；R286.02 文献标志码：A 文章编号：0253 - 2670(2011)03 - 0478 - 06 Flocculation procedure of water extract from Yangyin Qingfei Syrup with ZTC 1 + 1 1, 2 1 1 SUN Jiao , SUN Ze-zhan , KANG Yong 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China 2. School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, China Abstract: Objective To optimize the production procedure of Yangyin Qingfei Syrup (YQS), improve the clarity, and reserve more active components in water extract solution of YQS. Methods The natural macromolecule flocculant ZTC 1 + 1 was applied to purify the solution of YQS. By analyzing the turbidity degree of the upper solution and the retention rate of glycyrrhizic acid, the influences of the dosage of flocculant, temperature, mixing speed, and time on flocculation effect were investigated and the optimum process conditions were obtained. Results The optimum process conditions were as follows: the flocculation temperature was 30 ℃, the dosage of ZTC 1 + 1 was 0.6 g/L, the fast mixing speed was 450 r/min, and the fast mixing time was 2 min, the slow mixing speed was 50 r/min an