阿尔茨海默病β-淀粉样蛋白的近红外荧光探针研究进展-药学学报.pdf

528 药学学报 Acta Pharmaceutica Sinica 20 15, 50 (5): 528 534 尔茨海默病 -淀粉样蛋白的近红外荧光探针研究进展 蕾, 冯海威, 李玉艳* ( 中国药科大学药学院, 江苏 南京 2 10009) 摘要: 阿尔茨海默病 (Alzheimer ’s disease, AD) 是最常见的老年认知障碍疾病。随着社会老龄化越来越严重, AD 给患者和社会造成巨大的负担。大脑中A -淀粉样蛋白沉积是AD 患者早期发现、跟踪、预防和治疗的特异 性生物标志物。与正电子发射断层扫描及单光子发射计算机断层显像的核成像相 , 近红外荧光成像具有高灵 敏度、无创、安全、价廉等优点。因此用于近红外荧光成像的小分子探针成为目前的热点研究领域。本文综述 了标记A -淀粉样蛋白沉积的近红外荧光小分子探针必威体育精装版的研究进展。 关键词: 阿尔茨海默病; -淀粉样蛋白; 近红外荧光探针 中图分类号: R9 16 文献标识码: A 文章编号: 0513-4870 (20 15) 05-0528-07 Progress in the study of near-infrared fluorescent probes for the detection of -amyloid deposition in Alzheimer s disease * DU Lei, FENG Hai-wei, LI Yu-yan (School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China ) Abstract : Alzheimer ’s disease (AD) is the most common cause of cognitive impairment in older people. With the aging of society is more and more serious, AD caused great burden to patients and society. A is a classical biomarker of AD, which has been widely used in clinical diagnosis of AD patients. Compared with positron emission tomography (PET) and single photon emission computed tomography (SPECT), near infrared fluorescence imaging has many advantages including highly sensitive, non-invasive, safety and inexpensive. Therefore, many research groups have focused on developing the molecular probes of near-infrared fluorescence (NIRF) imaging. In this article, we will review the progress of the probes of NIRF. Key words: Alzheimer ’s disease; am