3q26 amplification is an effective negative triage test for lsil a historical prospective study3 q26放大是一种有效-分类测试lsil历史前瞻性研究.pdfVIP

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3q26 amplification is an effective negative triage test for lsil a historical prospective study3 q26放大是一种有效-分类测试lsil历史前瞻性研究.pdf

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3q26 amplification is an effective negative triage test for lsil a historical prospective study3 q26放大是一种有效-分类测试lsil历史前瞻性研究

3q26 Amplification Is an Effective Negative Triage Test for LSIL: A Historical Prospective Study 1,2,5 3 2 4 4 Erica R. Heitmann , Kamani M. Lankachandra , Jeff Wall , George D. Harris , Hollie J. McKinney , G. 6 6 6 6 6 Reza Jalali , Yogita Verma , Eric Kershnar , Michael W. Kilpatrick , Petros Tsipouras , Diane M. Harper1,2,4,5* 1 Department of Biomedical and Health Informatics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, United States of America, 2 Department of Obstetrics and Gynecology, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, United States of America, 3 Department of Pathology, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, United States of America, 4 Department of Community and Family Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, United States of America, 5 Center of Excellence, Women’s Health, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, United States of America, 6 Ikonisys, Inc., New Haven, Connecticut, United States of America Abstract Background: Women with low grade squamous intraepithelial lesions (LSIL) at cervical cancer screening are currently referred for further diagnostic work up despite 80% having no precancerous lesion. The primary purpose of this study is to measure the test characteristics of 3q26 chromosome gain (3q26 gain) as a host marker of carcinogenesis in women with LSIL. A negative triage test may allow these women to be followed by cytology alone without immediate referral to