5-hydroxytryptamine modulates migration, cytokine and chemokine release and t-cell priming capacity of dendritic cells in vitro and in vivo5 -羟色胺调节迁移,细胞因子和趋化因子释放和t细胞启动能力的树突细胞在体外和体内.pdfVIP

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5-hydroxytryptamine modulates migration, cytokine and chemokine release and t-cell priming capacity of dendritic cells in vitro and in vivo5 -羟色胺调节迁移,细胞因子和趋化因子释放和t细胞启动能力的树突细胞在体外和体内.pdf

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5-hydroxytryptamine modulates migration, cytokine and chemokine release and t-cell priming capacity of dendritic cells in vitro and in vivo5 -羟色胺调节迁移,细胞因子和趋化因子释放和t细胞启动能力的树突细胞在体外和体内

5-Hydroxytryptamine Modulates Migration, Cytokine and Chemokine Release and T-Cell Priming Capacity of Dendritic Cells In Vitro and In Vivo ¨ 1. ¨ 1. 1 1 1 Tobias Muller , Thorsten Durk , Britta Blumenthal , Melanie Grimm , Sanja Cicko , Elisabeth 3 1 3 2 2 Panther , Stephan Sorichter , Yared Herouy , Francesco Di Virgilio , Davide Ferrari , Johannes 4 1 Norgauer , Marco Idzko * 1 Department of Pneumology, University Hospital Freiburg, Freiburg, Germany, 2 Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy, 3 Department of Dermatology, University Hospital Freiburg, Freiburg, Germany, 4 Department of Dermatology, University Hospital Jena, Jena, Germany Abstract Beside its well described role in the central and peripheral nervous system 5-hydroxytryptamine (5-HT), commonly known as serotonin, is also a potent immuno-modulator. Serotoninergic receptors (5-HTR) are expressed by a broad range of inflammatory cell types, including dendritic cells (DCs). In this study, we aimed to further characterize the immuno- biological properties of serotoninergic receptors on human monocyte-derived DCs. 5-HT was able to induce oriented migration in immature but not in LPS-matured DCs via activation of 5-HTR1 and 5-HTR2 receptor subtypes. Accordingly, 5- HT also increased migration of pulmonary DCs to draining lymph nodes in vivo. By binding to 5-HTR3, 5-HTR4 and 5-HTR7 receptors, 5-HT up-regulated produc