60 kd ro and nrnp a frequently initiate human lupus autoimmunity60 kd ro和nrnp人类狼疮频繁启动自身免疫.pdfVIP

60 kD Ro and nRNP A Frequently Initiate Human Lupus Autoimmunity 1,2,3 1 1,2,3 1 Latisha D. Heinlen , Micah T. McClain , Lauren L. Ritterhouse , Benjamin F. Bruner , Colin C. 4 5 1,2,3 2,3,6,7 Edgerton , Michael P. Keith , Judith A. James , John B. Harley * 1 Department of Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, 2 Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, 3 Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, 4 Walter Reed Army Medical Center, Washington, District of Columbia, United States of America, 5 National Naval Medical Center, Bethesda, Maryland, United States of America, 6 United States Department of Veterans Affairs, Oklahoma City, Oklahoma, United States of America, 7 Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America Abstract Systemic lupus erythematosus (SLE) is a clinically heterogeneous, humoral autoimmune disorder. The unifying feature among SLE patients is the production of large quantities of autoantibodies. Serum samples from 129 patients collected before the onset of SLE and while in the United States military were evaluated for early pre-clinical serologic events. The first available positive serum sample frequently already contained multiple autoantibody specificities (65%). However, in 34 SLE patients the earliest pre-clinical serum sample positive f