a comparative study of leptospirosis and dengue in thai children钩端螺旋体病和登革热的比较研究泰国的孩子.pdfVIP

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a comparative study of leptospirosis and dengue in thai children钩端螺旋体病和登革热的比较研究泰国的孩子.pdf

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a comparative study of leptospirosis and dengue in thai children钩端螺旋体病和登革热的比较研究泰国的孩子

A Comparative Study of Leptospirosis and Dengue in Thai Children 1 2 3 2 2 Daniel H. Libraty *, Khin S. A. Myint , Clinton K. Murray , Robert V. Gibbons , Mammen P. Mammen , 2 4 2 2 5 Timothy P. Endy , Wenjun Li , David W. Vaughn , Ananda Nisalak , Siripen Kalayanarooj , Duane R. 3 1 1 1 Hospenthal , Sharone Green , Alan L. Rothman , Francis A. Ennis 1 Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, 2 Department of Virology, US Army Medical Component, Armed Forces Research Institute for Medical Sciences, Bangkok, Thailand, 3 Brooke Army Medical Center, Ft. Sam Houston, Texas, United States of America, 4 Department of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, 5 Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok, Thailand Abstract Background: Leptospirosis is an emerging zoonosis that is often under-recognized in children and commonly confused with dengue in tropical settings. An enhanced ability to distinguish leptospirosis from dengue in children would guide clinicians and public health personnel in the appropriate use of limited healthcare resources. Methodology/Principal Findings: We conducted a prospective, hospital-based, study of children with acute febrile illnesses and dengue in Thailand. Among the children without dengue, we identified those with leptospirosis using anti-le