有哪些信誉好的足球投注网站a comprehensive molecular interaction map for rheumatoid arthritis一个全面的分子间相互作用对类风湿性关节炎地图.pdfVIP
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a comprehensive molecular interaction map for rheumatoid arthritis一个全面的分子间相互作用对类风湿性关节炎地图
A Comprehensive Molecular Interaction Map for
Rheumatoid Arthritis
Gang Wu., Lisha Zhu., Jennifer E. Dent., Christine Nardini*
Group of Clinical Genomic Networks, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,
Shanghai, People’s Republic of China
Abstract
Background: Computational biology contributes to a variety of areas related to life sciences and, due to the growing impact
of translational medicine - the scientific approach to medicine in tight relation with basic science -, it is becoming an
important player in clinical-related areas. In this study, we use computation methods in order to improve our understanding
of the complex interactions that occur between molecules related to Rheumatoid Arthritis (RA).
Methodology: Due to the complexity of the disease and the numerous molecular players involved, we devised a method to
construct a systemic network of interactions of the processes ongoing in patients affected by RA. The network is based on
high-throughput data, refined semi-automatically with carefully curated literature-based information. This global network
has then been topologically analysed, as a whole and tissue-specifically, in order to translate the experimental molecular
connections into topological motifs meaningful in the identification of tissue-specific markers and targets in the diagnosis,
and possibly in the therapy, of RA.
Significance: We find that some nodes in the network that prove to be topologically important, in particular AKT2, IL6,
MAPK1 and TP53, are also known to be associated with drugs used for the treatment of RA. Importantly, based on
topological consideration, we are also able to suggest CRKL as a novel potentially relevant molecule for the diagnosis or
treatment of RA. This type of finding proves the potential of i
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