有哪些信誉好的足球投注网站a comprehensive sequence and disease correlation analyses for the c-terminal region of caga protein of helicobacter pylori综合序列和疾病相关性分析caga蛋白c端地区幽门螺杆菌.pdfVIP
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a comprehensive sequence and disease correlation analyses for the c-terminal region of caga protein of helicobacter pylori综合序列和疾病相关性分析caga蛋白c端地区幽门螺杆菌
A Comprehensive Sequence and Disease Correlation
Analyses for the C-Terminal Region of CagA Protein of
Helicobacter pylori
1 2,3 1 1 1
Youlin Xia , Yoshio Yamaoka *, Qi Zhu , Ivan Matha , Xiaolian Gao *
1 Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States of America, 2 Department of Medicine-Gastroenterology, Veterans Affairs
Medical Center and Baylor College of Medicine, Houston, Texas, United States of America, 3 Department of Environmental and Preventive Medicine, Oita University
Faculty of Medicine, Yufu, Japan
Abstract
Chronic Helicobacter pylori infection is known to be associated with the development of peptic ulcer, gastric cancer and
gastric lymphoma. Currently, the bacterial factors of H. pylori are reported to be important in the development of
gastroduodenal diseases. CagA protein, encoded by the cagA, is the best studied virulence factor of H. pylori. The
pathogenic CagA protein contains a highly polymorphic Glu-Pro-Ile-Tyr-Ala (EPIYA) repeat region in the C-terminal. This
repeat region is reported to be involved in the pathogenesis of gastroduodenal diseases. The segments containing EPIYA
motifs have been designated as segments A, B, C, and D; however the classification and disease relation are still unclear. This
study used 560 unique CagA sequences containing 1,796 EPIYA motifs collected from public resources, including 274
Western and 286 East Asian strains with clinical data obtained from 433 entries. Fifteen types of EPIYA or EPIYA-like
sequences are defined. In addition to four previously reported major segment types, several minor segment types (e.g.,
segm
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