a comprehensive resource of interacting protein regions for refining human transcription factor networks蛋白质相互作用区域的综合资源提炼人类转录因子网络.pdfVIP

A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks 1,2 1 2 1 1 Etsuko Miyamoto-Sato *, Shigeo Fujimori , Masamichi Ishizaka , Naoya Hirai , Kazuyo Masuoka , 3 4 1,2 2 3 Rintaro Saito , Yosuke Ozawa , Katsuya Hino , Takanori Washio , Masaru Tomita , Tatsuhiro Yamashita2,5, Tomohiro Oshikubo2,6, Hidetoshi Akasaka2,6, Jun Sugiyama2,7, Yasuo Matsumoto2,8, Hiroshi Yanagawa1,2* 1 Advanced Research Centers, Keio University, Yokohama, Japan, 2 Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan, 3 Department of Environment and Information Studies, Keio University, Fujisawa, Japan, 4 Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Japan, 5 BioIT Business Development Unit, Fujitsu Limited, Chiba, Japan, 6 Production Solution Business Unit, Production Solution Division, Solutions and Services Department, Fujitsu Advanced Engineering Limited, Tokyo, Japan, 7 Special Suite Team, Custom Primer Production Department, Haneda Laboratories, Invitrogen Japan K.K., Tokyo, Japan, 8 Automation, QIAGEN K.K., Tokyo, Japan Abstract Large-scale data sets of protein-protein interactions (PPIs) are a valuable resource for mapping and analysis of the topological and dynamic features of interactome networks. The currently available large-scale PPI data sets only contain information on interaction partners. The data presented in this study also include the sequences involved in the interactions