a deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, brugia malayi深度测序方法比较分析丝虫的生命周期阶段的转录组,与象皮病马来.pdfVIP

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a deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, brugia malayi深度测序方法比较分析丝虫的生命周期阶段的转录组,与象皮病马来.pdf

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a deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, brugia malayi深度测序方法比较分析丝虫的生命周期阶段的转录组,与象皮病马来

A Deep Sequencing Approach to Comparatively Analyze the Transcriptome of Lifecycle Stages of the Filarial Worm, Brugia malayi 1 2 3 3 3 Young-Jun Choi , Elodie Ghedin , Matthew Berriman , Jacqueline McQuillan , Nancy Holroyd , 1 1 4 George F. Mayhew , Bruce M. Christensen , Michelle L. Michalski * 1 Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 Department of Computational and Systems Biology, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 3 The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, 4 Department of Biology and Microbiology, University of Wisconsin Oshkosh, Oshkosh, Wisconsin, United States of America Abstract Background: Developing intervention strategies for the control of parasitic nematodes continues to be a significant challenge. Genomic and post-genomic approaches play an increasingly important role for providing fundamental molecular information about these parasites, thus enhancing basic as well as translational research. Here we report a comprehensive genome-wide survey of the developmental transcriptome of the human filarial parasite Brugia malayi. Methodology/Principal Findings: Using deep sequencing, we profiled the transcriptome of eggs and embryos, immature (#3 days of age) and mature microfilariae (MF), third- and fourth-stage larvae (L3 and L4), and adult male and female worms. Comparative analysis across these stages provided a detailed overview of the molecular repertoires that define and differentiate disti