a detailed phylogenetic analysis of fiv in the united statesfiv的详细的系统发育分析在美国.pdfVIP

A Detailed Phylogenetic Analysis of FIV in the United States Eric A. Weaver* Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America Abstract Background: Feline immunodeficiency virus (FIV) is a lentivirus associated with AIDS-like illnesses in cats and has been used as a model for the study of human immunodeficiency virus (HIV). A feature of HIV and FIV infection is the continually increasing divergence among viral isolates between different individuals, as well as within the same individuals. Methodology/Principal Findings: The goal of this study was to determine the phylogenetic patterns of viral isolates obtained within the United States (U.S.) by focusing on the variable, V3-V4, region of the FIV envelope gene. Conclusions/Significance: Data indicate that FIV, from within the U.S., localize to four viral clades, A, B, C, and F. Also shown is the geographic isolation of strains where clade A and clade B are found predominately on the west coast; however, clade B is also found throughout the U.S. and represents the predominant clade. This study presents a complete and conclusive analysis of FIV isolates from within the U.S. and may be used as the essential basis for the development of an effective multi- clade vaccine. Citation: Weaver EA (2010) A Detailed Phylogenetic Analysis of FIV in the United States. PLoS ONE 5(8): e12004. doi:10.1371/journal.pone.0012004 Editor: Darren P. Martin, Institute of Infectious Disease and Molecular Medicine, South Africa Received May 19, 2010; Accepted July 12, 2010; Published August 9, 2010 Copyright: 2010 Eric A. Weaver. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the o