a defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells定义和xeno-free文化方法使clinical-grade人类胚胎,诱导多功能脂肪干细胞.pdfVIP

a defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells定义和xeno-free文化方法使clinical-grade人类胚胎,诱导多功能脂肪干细胞.pdf

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a defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells定义和xeno-free文化方法使clinical-grade人类胚胎,诱导多功能脂肪干细胞

A Defined and Xeno-Free Culture Method Enabling the Establishment of Clinical-Grade Human Embryonic, Induced Pluripotent and Adipose Stem Cells 1 1 2 1 1 Kristiina Rajala *, Bettina Lindroos , Samer M. Hussein , Riikka S. Lappalainen , Mari Pekkanen-Mattila , 3 ¨ 4 1 1 ¨ 1 Jose Inzunza , Bjorn Rozell , Susanna Miettinen , Susanna Narkilahti , Erja Kerkela , Katriina Aalto- ¨ ¨ 1 2 1,5,6 7 1 Setala , Timo Otonkoski , Riitta Suuronen , Outi Hovatta , Heli Skottman 1 Regea - Institute for Regenerative Medicine, University of Tampere, Tampere University Hospital, Tampere, Finland, 2 Biomedicum Stem Cell Center and Children’s Hospital, University of Helsinki, Helsinki, Finland, 3 Division of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden, 4 Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 5 Department of Biomedical Engineering, Tampere University of Technology, Tampere, Finland, 6 Department of Eye, Ear and Oral Diseases, Tampere University Hospital, Tampere, Finland, 7 Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Abstract Background: The growth of stem cells in in vitro conditions requires optimal balance between signals mediating cell survival, proliferation, and self-renewal. For clinical application of stem cells, the use of completely defined c

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