a dinucleotide deletion in cd24 confers protection against autoimmune diseases二核苷酸删除cd24授予保护自身免疫性疾病.pdfVIP

A Dinucleotide Deletion in CD24 Confers Protection against Autoimmune Diseases 1,2 3 4 3 5 1,2 5 Lizhong Wang , Shili Lin , Kottil W. Rammohan , Zhenqiu Liu , Jin-qing Liu , Run-hua Liu , Nikki Guinther , 4 6 5 6 7 7 7 Judy Lima , Qunmin Zhou , Tony Wang , Xincheng Zheng , Dan J. Birmingham , Brad H. Rovin , Lee A. Hebert , Yeeling Wu8 4 7 8 1,2 1,2* , D. Joanne Lynn , Glenn Cooke , C. Yung Yu , Pan Zheng , Yang Liu 1 Division of Immunotherapy, Department of Surgery, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America, 2 Program of Molecular Mechanisms of Disease, University of Michigan, Ann Arbor, Michigan, United States of America, 3 Department of Statistics, The Ohio State University, Columbus, Ohio, United States of America, 4 Department of Neurology, The Ohio State University, Columbus, Ohio, United States of America, 5 Department of Pathology, The Ohio State University, Columbus, Ohio, United States of America, 6 OncoImmune, Columbus, Ohio, United States of America, 7 Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America, 8 Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America It is generally believed that susceptibility to both organ-specific and systemic autoimmune diseases is under polygenic control. Although multiple genes have been implicated in each type of autoimmune disease, few are known to have a significant impact on both. Here, we investigated the significance of polymorphisms in t