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a dna-binding protein helps repair breaks in dna double helixdna结合蛋白质帮助修复断裂在dna双螺旋结构
Research Digest
Synopses of Research Articles
A New Gene That Shapes Mouse Pigmentation Patterning
Scientists have long known that variation in animal color the protein nonfunctional. The researchers made certain that
patterns carry far more than cosmetic signifi cance. Darwin Tbx15 really is the droopy ear gene by deleting most of the
fi rst connected pigmentation with adaptive advantage, noting gene’s coding region and showing that this “knocked-out’’ gene
that male fi nches with bright red plumage enjoyed greater produces the typical droopy ear mouse.
reproductive success than their drab competitors. Explaining The pattern of embryonic Tbx15 expression—determined
why coloration confers such advantages, however, has proved by observing messenger RNA transcripts in developing
somewhat easier than showing how it arises. Biologists studying tissues of the head, trunk, and limbs—suggests that early
how neighboring regions of the vertebrate body plan develop expression of Tbx15 in the dorsal fl ank sets coordinates for
differences in appearance and form dorsoventral differences in hair
have identifi ed a small number length and pigmentation. Candille
of signaling pathways common et al. demonstrate that the regional
to all animals. How and whether pigment differences characteristic of
these pathways also control the adults is indeed established soon after
developmental expression and variation
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