a dominant clone of leptospira interrogans associated with an outbreak of human leptospirosis in thailand主导的克隆,钩端螺旋体interrogans在泰国与人类钩端螺旋体病的爆发.pdfVIP

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a dominant clone of leptospira interrogans associated with an outbreak of human leptospirosis in thailand主导的克隆,钩端螺旋体interrogans在泰国与人类钩端螺旋体病的爆发.pdf

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a dominant clone of leptospira interrogans associated with an outbreak of human leptospirosis in thailand主导的克隆,钩端螺旋体interrogans在泰国与人类钩端螺旋体病的爆发

A Dominant Clone of Leptospira interrogans Associated with an Outbreak of Human Leptospirosis in Thailand 1 1 1 2 Janjira Thaipadungpanit , Vanaporn Wuthiekanun , Wirongrong Chierakul , Lee D. Smythe , 3 4 4 2 Wimol Petkanchanapong , Roongrueng Limpaiboon , Apichat Apiwatanaporn , Andrew T. Slack , 5 1,6 7 1,6 1,6 Yupin Suputtamongkol , Nicholas J. White , Edward J. Feil , Nicholas P. J. Day , Sharon J. Peacock * 1 Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 2 WHO/FAO/OIE Collaborating Centre for Reference Research on Leptospirosis, Centre for Public Health Sciences, Queensland Health Scientific Services, Brisbane, Australia, 3 National Institute of Health, Nonthaburi Province, Thailand, 4 Medical Department, Udon Thani General Hospital, Udon Thani, Thailand, 5 Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, 6 Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom, 7 Department of Biology and Biochemistry, University of Bath, United Kingdom Abstract Background: A sustained outbreak of leptospirosis occurred in northeast Thailand between 1999 and 2003, the basis for which was unknown. Methods and Findings: A prospective study was conducted between 2000 and 2005 to identify