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a dominantly acting murine allele of mcm4 causes chromosomal abnormalities and promotes tumorigenesis主代理小鼠等位基因mcm4导致染色体异常和促进肿瘤发生
A Dominantly Acting Murine Allele of Mcm4 Causes
Chromosomal Abnormalities and Promotes
Tumorigenesis
1 2 1 1 1
Bruce N. Bagley , Thomas M. Keane , Vilena I. Maklakova , Jonathon G. Marshall , Rachael A. Lester ,
1 1 3 3 4
Michelle M. Cancel , Alex R. Paulsen , Laura E. Bendzick , Raha A. Been , Scott C. Kogan ,
5 6 2 1
Robert T. Cormier , Christina Kendziorski , David J. Adams , Lara S. Collier *
1 School of Pharmacy and UW Carbone Cancer Center, University of Wisconsin Madison, Madison, Wisconsin, United States of America, 2 Experimental Cancer Genetics,
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, 3 Department of Genetics, Cell Biology, and Development, Masonic Cancer
Center, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America, 4 Department of Laboratory Medicine and Helen Diller Family
Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America, 5 Department of Biomedical Sciences, University
of Minnesota Medical School Duluth, Duluth, Minnesota, United States of America, 6 Department of Biostatistics and Medical Informatics and UW Carbone Cancer Center,
University of Wisconsin Madison, Madison, Wisconsin, United States of America
Abstract
Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called
Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penet
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