a duplication cnv that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men重复cnv,传达特征相互代谢综合征和防止食源性肥胖小鼠和人.pdfVIP

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2017-09-05 发布于上海
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a duplication cnv that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men重复cnv,传达特征相互代谢综合征和防止食源性肥胖小鼠和人.pdf

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a duplication cnv that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men重复cnv,传达特征相互代谢综合征和防止食源性肥胖小鼠和人

A Duplication CNV That Conveys Traits Reciprocal to Metabolic Syndrome and Protects against Diet-Induced Obesity in Mice and Men 1 2,3,4 1,5 1 1 6 Melanie Lacaria , Pradip Saha , Lorraine Potocki , Weimin Bi , Jiong Yan , Santhosh Girirajan , 7 6,7 8 2,3,4 1,5,9 1 Brooke Burns , Sarah Elsea , Katherina Walz , Lawrence Chan , James R. Lupski *, Wenli Gu 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, 2 Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston, Texas, United States of America, 3 Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America, 4 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, 5 Texas Children’s Hospital, Houston, Texas, United States of America, 6 Department of Molecular and Human Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America, 7 Department of Pediatrics, Virginia Commonwealth University, Richmond, Virginia, United States of America, 8 Department of Human Genetics, University of Miami, Miami, Florida, United States of America, 9 Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America Abstract The functional contribution of CNV to human biology and disease pathophysiology has undergone limited exploration. Recent observations in humans indicate a tentative link between CNV and weight regulation. Smith-Magenis syndrome (SMS), manifest