a fish-specific transposable element shapes the repertoire of p53 target genes in zebrafish一个fish-specific转座因子形状目标p53基因在斑马鱼的曲目.pdfVIP

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a fish-specific transposable element shapes the repertoire of p53 target genes in zebrafish一个fish-specific转座因子形状目标p53基因在斑马鱼的曲目.pdf

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a fish-specific transposable element shapes the repertoire of p53 target genes in zebrafish一个fish-specific转座因子形状目标p53基因在斑马鱼的曲目

A Fish-Specific Transposable Element Shapes the Repertoire of p53 Target Genes in Zebrafish 1. 2,1. 3 1 1 Lucia Micale , Maria Nicla Loviglio , Marta Manzoni , Carmela Fusco , Bartolomeo Augello , 2 1 3 3 2 Eugenia Migliavacca , Grazia Cotugno , Eugenio Monti , Giuseppe Borsani , Alexandre Reymond * , 1 Giuseppe Merla * 1 Medical Genetics Unit, IRCCS ‘‘Casa Sollievo della Sofferenza’’, San Giovanni Rotondo, Italy, 2 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, 3 Department of Biomedical Science and Biotechnology, University of Brescia, Brescia, Italy Abstract Transposable elements, as major components of most eukaryotic organisms’ genomes, define their structural organization and plasticity. They supply host genomes with functional elements, for example, binding sites of the pleiotropic master transcription factor p53 were identified in LINE1, Alu and LTR repeats in the human genome. Similarly, in this report we reveal the role of zebrafish (Danio rerio) EnSpmN6_DR non-autonomous DNA transposon in shaping the repertoire of the p53 target genes. The multiple copies of EnSpmN6_DR and their embedded p53 responsive elements drive in several instances p53-dependent transcriptional modulation of the adjacent gene, whose human orthologs were frequently previously annotated as p53 targets. These transposons define predominantly a set of target genes whose human orthologs contribute to neuronal morphogenesis, axonogenesis, synaptic transmission and the regul